洪学传,
汉族,是一名教授,任职于
武汉大学药学院。他毕业于
天津大学,并担任楚天学者特聘教授。截至2019年7月,他已发表13篇论文。
学习简历
1993.9 - 1997.7 天津大学攻读
应用化学系精细化工专业
学士1993.9 - 1997.7 天津大学攻读管理学院技术经济学士双学位
1997.9 - 1999.11 天津大学免试攻读化工学院应用化学专业硕士学位
1999.12 -2000.7
北海道大学药学院和触媒化学研究中心研修生
2001.1 - 2005.7 美国
密苏里大学哥伦比亚分校攻读有机化学博士学位
工作简历
1997.9 - 1999.11
天津大学化工学院97级本科生辅导员
1999.12–2000.07 日本北海道大学,药学院,研修生
2005.9 - 2007.9美国爱默里大学博士后研究员
2007.10- 2010. 10AMRI, Albany, NY, USA 资深科学家
2010.10- 2011.4
武汉大学药学院, 教授
2011.5-至今武汉大学药学院, 楚天学者特聘教授,武汉大学药学院
邓子新院士创新团队成员。
2017.12 – 至今
西藏大学医学院教授,博士生导师
业绩概要
1)国内国际核心
化学期刊上发表论文37篇及英文专著一章。
2)率先发现了以手性亚
亚胺(sulfoximine)为手性助剂的不对称的1,4-加成反应, 使在芳香基团,
杂环化合物共扼环的α位引入手性
烷基手性中心更加容易。反应具有广泛 的普遍性和绝对的立体选择性。
3)在美国国立卫生研究院(NIH),
结核病 Antimicrobial Acquisition and Coordinating Facility (TAACF) 和 CV Therapeutics 的支持下, 利用这特定的
化学设计, 合成了一系列具有绝对构像的抗结核病的天然或非天然化合物例如(+)-curcumeme, (+)-curcuphenol, pesudoteroxazole, erogorgiaene, colombiasin A 和 elisapterosin B及分子改造, 开发出了一些选择性地高, 毒性小的抗结核剂。
4)发现用改进的aza-Achmatowicz 方法合成多取代
吡咯。确定(II)
催化吲环加成串联反应的相对立体构像。设计, 合成了一系列具有高
生物活性的天然化合物例如kopsifoline的核 心结构。
5)曾从事各类癌症药物和
肥胖症的小分子药物等发现,合成, 研制及工业开发。其中一个临床III药在2009年9月得到美国FDA批准。
获奖情况
2004Breckenridge Lyons Award for Outstanding Graduate Research, University of Missouri-
Colombia2004
Gordon Research Conference on Organic Reactions and Process Chair Award.
2014年获武汉市第三批“黄鹤英才”人才计划。
2014年获
美国化学会组织颁发的第九届世界华人药学会最佳报告奖。
2016年
武汉大学珞珈学者特聘教授,武汉大学医学部医学突出贡献奖,武汉大学
朱裕璧医学奖。
研究领域
药物化学,有机化学,分子影像(Molecular Imaging)
研究兴趣与方向
1.活性天然产物的全合成
2.化学合成药物的开发与研究
3.运用现代生物学技术进行药物开发
4.用于肿瘤光声成像的分子探针的研制和开发
已发表的学术论文
著作:
1.“Recent Progress in the
化学 of 2,1-Benzothiazines”
Xuechuan hong; Michael Harmata. Progress in Hetereocyclic Chemistry, Chapter 1, G. W. Gribble and J. A. joule, eds, Pergamon Press, Vol 20, pp 1–43 (2008)
发表论文:
1.“Metal-free direct amidation of peptidyl
硫醇 esters with -amino acid esters.” Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng, Green Chem., 2011, 13“The Intramolecular, Stereoselective Addition of Sulfoximine Carbanions to α,β-unsaturated Esters.”Michael Harmata; Xuechuan Hong. J. Am. Chem.l Soc.2003, 125(19), 5754–5756. , 2723
2.
3. “Asymmetric Organocatalysis of [4+3] Cycloaddition Reactions.” Michael Harmata; Sunil K.
Ghosh; Xuechuan Hong; Sumrit Wacharasindhu; Patrick Kirchhoe
铁 J. Am. Chem.l Soc. 2003, 125(8), 2058–2059.
4. “A Cycloaddition Protocol for the Assembly of the Heterocyclic Framework Associated with the Kopsifoline alkaloids.”Xuechuan Hong; Stefan France; José M. Mejía-Oneto; Albert Padwa. Org. Lett. 2006, 8, 5141–5144.
5. “Benzothiazines in Synthesis. A Total Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong. Org. Lett. 2005, 7(16), 3581–3583.
6.“Benzothiazines in Synthesis. Toward the Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong; Charles L. Barnes. Org. Lett.2004, 6(13), 2201–2203.
7."Benzothiazines in Organic Synthesis.The Preparation of Enantiomerically Pure 4-Substituted Quinolones” Michael Harmata; Xuechuan Hong. Org. Lett. 2007, 9, 2901–2904.
8.“Benzothiazines in Synthesis. Stereoselective Synthesis of Erogorgiaene.”Michael Harmata; Xuechuan Hong;Peter R. Schreiner. J. Org. Chem.2008, 73, 1290–1296.
9. “Synthesis of 2,4-Disubstituted Pyrroles by Rearrangements of 2-Furanyl Carbamates.”Sezgin Kiren; Xuechuan Hong; Carolyn A. Leverett; Albert Padwa.Org. Lett. 2009, 11(6), 1233–1235.
10. “A dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.” Xuechuan Hong; Stefan France; Albert Padwa. Tetrahedron, 2007, 63, 5962–5976.
11. “
铑 Carbenoid Induced Cycloadditions of Diazo Ketoamides
across Indolyl π-Bonds.”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Synlett, 2007, 775–779.
12. “Lewis Acid Promoted a-Hydroxy b-Dicarbonyl to a-Ketol Ester Rearrangement.” Xuechuan Hongıa-Oneto; Albert Padwa. Tetrahedron Lett. 2006, 47, 8387–8390.;Jose M. Mej
13. “Photodesulfonylation of Indoles Initiated by Electron Transfer from
三乙胺”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Tetrahedron Lett.2006, 47, 2409–2412.
14. “
钯catalyzed Cross-coupling Reactions of a Sulfoximine with Aryl Dichlorides under
微波 Irradiation.”Michael Harmata; Xuechuan Hong. Synlett, 2007, 969–973.
国际学术会议报告
1. “Studies of the
化学 of 2,1-Benzothiazines and an Approach to the Synthesis of Antitubercular Natural Products.” Xuechuan Hong*nd International Symposium on Organic Synthesis and Drug Development,Nanjing, China, October 14-16, 2010.. Presented at 2
2. “Benzothiazines in Synthesis. Synthesis of Enantiomerically Pure 3,4-Dihydroquinolin-2(1H)-ones.” Michael Harmata; Xuechuan Hong*. ORGN-029l presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.
3. "Benzothiazines in Synthesis. A Route to Chiral Cyclobutanes” Michael Harmata; Weijiang Ying and Xuechuan Hong. ORGN-515 presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.
4.“Benzothiazines in Synthesis. Stereoselective Synthesis of Diastereomers of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. ORGN-060 presented present at the 228 National Meeting of the American Chemical Society,
费城, August 22-26, 2004.
5. “
微波assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. ORGN-165 presented at the 228 National Meeting of the American Chemical Society,
费城, August 22-26, 2004.
6. “Towards a Synthesis of Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.
7. “
微波assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.
8.“Benzothiazines in Synthesis. Towards Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. ORGN-061 presented at the 228National Meeting of the American Chemical Society,
费城, August 22-26, 2004.
9. “Towards a Synthesis of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. Paper #48 presented at the 38 Annual Midwest Regional Meeting of the American Chemical Society,
Colombia, November 5-7, 2003。