柳红，女，山西太原人。1999年毕业于中国药科大学获理学博士学位。现任中国科学院上海药物研究所研究员、博士生导师

从事药物化学、药物设计、化学生物学研究。

1991.9.1-1993.8.31，山东新华制药厂四车间，助理工程师。

1999.8.1-2001.8.31，中国科学院上海药物研究所，博士。

2002.2.1-2002.10.30，美国University of Texas Medical Branch 大学，访问科学家（Visiting Scientist）。

2005.1.1-2005.10.30，美国University of Texas Medical Branch 大学，访问科学家（Visiting Scientist）。

2001.9.1-2006.6.30，中国科学院上海药物研究所，副研究员、硕士生导师。

2006.1.7-至今，中国科学院上海药物研究所，研究员、博士生导师。

曾担任中国药学会药物化学专业委员会委员、上海药学会药物化学专业委员会委员、上海市妇联妇代会执委委员等，任药学学报、中国药物化学杂志编委会成员;

1.发展高效的合成方法学构建类药性(手性)杂环化合物库

2.针对重大疾病的创新药物研究

（1）抗糖尿病药物DPPIV抑制剂的发现研究

（2）抗阿尔兹海默症药物的发现研究

（3）靶向α1A-AR的新型抗前列腺增生药物的发现研究

（4）抗肿瘤药物c-Met抑制剂的发现研究

（5）抗HIV药物CCR5抑制剂的发现研究

承担科研项目情况

1.国家自然科学基金重大研究计划重点支持项目，S1P在肿瘤细胞糖脂代谢异常及非可控性炎症向肿瘤癌转化中的分子调控，项目负责人，2013.01-2016.12

2.国家科技十二五重大专项，抗糖尿病类LJN系列新药候选物的临床前研究，项目负责人，2012.01-2015.12

3.上海市优秀学术带头人计划，手性药物优势骨架化合物库的构建与新药设计与发现研究，项目负责人，2012.07-2014.06

4.国家杰出青年基金，药物化学，项目负责人，2011.01-2014.12

5.欧盟F7框架计划SILVER项目，Small-molecule inhibitor leads versus emerging and neglected 核糖核酸 viruses，中方负责人，2010.10-2014.09

6.科技部对欧盟合作项目，抗肠病毒属（EV68、EV71）小分子抑制剂研究，项目负责人，2011.12-2013.12

7.国家高技术研究发展计划（863）基金JG3，DC06及DC032的研究与开发，项目负责人，2006.11-2010.12

8.国家自然科学基金项目，新型钾离子通道阻滞剂的发现及其亚型的选择性和功能研究，项目负责人，2008.1-2011.12

研究领域

主要从事药物化学基础和应用基础的研究工作，研究领域涉及药物化学、有机合成和计算机辅助药物设计等学科。作为课题负责人先后承担了国家高技术“863”计划、国家自然科学基金、上海市科委等基金项目。近年来，围绕新结构类型先导化合物的合成，开展新的有机合成方法学研究，在化学 \u0026 Biology、Journal of Biological Chemistry、Journal of Medicinal Chemistry、Organic Letters、 Journal of Organic Chemistry、Journal of Combinatorial Chemistry、Biophysical Journal、Journal of 药理学 Experimental Therapeutics、Current Medicinal Chemistry、Bioorganic \u0026 Medicinal 化学、Tetrahedron Letters和Drug Metabolism and Disposition等杂志上发表国内外论文百余篇。参加5本专著的编写，申请专利30项，获得专利证书5项。

代表论著

1. Shengbin Zhou, Jiang Wang, Xia Chen, José Luis Aceña Vadim A. Soloshonok,* and Hong Liu*. Chemical Kinetic Resolution of Unprotected b-Substituted-b-Amino Acids Using Recyclable Chiral Ligands. Angewandte Chemie. 2014, 53, 7883-7886. (IF=13.734).

2. Jiang Wang, José Luis Aceña, Santos Fustero, Carlos del Pozo, María Sánchez-Roselló, Vadim A. Soloshonok,* Alexander E. Sorochinsky, , Hong Liu*. Fluorine in Pharmaceutical Industry; Fluorinated Drugs Introduced to the Market in the Last Decade. Chemical Reviews. 2014,114, 2432−2506. (IF=41.298)

3. Wei Yang, Liliang Huang, Hong Liu, Wei Wang* and Hao Li*. Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines. Chem Comm 2013, 49, 4667-4669. (IF=6.378)

4. Enguang Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li, Deju Ye, Jiang Wang, Jian-Ping 左姓, Kyoung Tai No, Mingyue Zheng, Weiliang Zhu, * Wei Tang, * Baik-Lin Seong,* Hualiang Jiang, and Hong Liu* Structure-Based 设计, Synthesis of C-1 and C-4 modified analogs of zanamivir as neuraminidase inhibitors. Journal of Medicinal 化学 2013, 56, 671-684. (IF=5.614)

5. Jiahui Wu, Dengyou Zhang, Lei Chen, Jianneng Li, Jianling Wang, Chengqing Ning,Niefang Yu, Fei Zhao,Dongying Chen,Xiaoyan Chen,Kaixian Chen, Hualiang Jiang, Hong Liu*,and Dongxiang Liu*, Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate Journal of Medicinal 化学 2013, 56,761-780. (IF=5.614)

6. Shengtao Xu, Yu Zhou, Jinyi Xu*, Hualiang Jiang, and Hong Liu* Gold-catalyzed Michael Addition/Intramolecular Annulation Cascade: an Effective Pathway for the Chemoselective- and Regioselective Synthesis of Tetracyclic Indole Derivatives in H₂O Green 化学 2013,15,718-726. (IF=6.828)

7. Lei Zhang, Fei Zhao, Mingyue Zheng, Yun Zhai and Hong Liu* Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-DNA加合物 under 微波 heating Chem Comm 2013,49,2894-2896. (IF=6.378)

8. Daizong Lin, Jiang Wang, Xu Zhang, Shengbin Zhou, Jie Lian, Hualiang Jiang and Hong Liu* Highly diastereoselective synthesis of 3-indolylglycines Chem Comm 2013,49,2575-2577. (IF=6.378)

9. Jinfang Wang, Yu Zhou,* Lei Zhang, Zeng Li, Xianjie Chen and Hong Liu*. Asymmetric Michael Addition of N-tert-Butanesulfinyl Imidates: an Efficient Strategy for the Synthesis of (R)-3-Substituted Indanone Derivertives. Organic Letters. 2013,15,1508-1511. (IF=6.142)

10. Xianjie Chen , Hui Chen, Xun Ji, Hualiang Jiang, Zhu-Jun Yao, and Hong Liu*. Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro [pyrrolidin-3, 2′-羟吲哚] Derivatives Organic Letters. 2013,15,1846-1849. (IF=6.142)

11. Enguang Feng, Yu Zhou, Fei Zhao, Xianjie Chen, Lei Zhang, Hualiang Jiang, Hong Liu* Gold-catalyzed tandem reaction in H₂O: An efficient and convenient synthesis of fused polycyclic indoles. Green 化学. 2012, 14, 1888-1895. (IF=6.828)

12. Xianjie Chen, Wei Zhu, Wangke Qian, Enguang Feng, Yu Zhou, Jinfang Wang, Hualiang Jiang, Zhu-Jun Yao,* and Hong Liu.* Highly Enantioselective of 2-Oxindoles-3-carboxylate Ester to Nitroolefins Promoted by Cinchona Alkaloid 硫脲Brønsted Acid Co-catalysts. Advanced Synthesis \u0026 Catalysis 2012, 354, 2151-2156. (IF=5.353)

13. Wangke Qian, Lei Zhang, Haifeng Sun, Hualiang Jiang, and Hong Liu* 微波assisted One-step Synthesis of Acetophenones via 钯catalyzed Regioselective Arylation of Vinyloxy-三甲基硅烷 Advanced Synthesis \u0026 Catalysis 2012, 354, 3231-3236. (IF=5.535)

14. Qian Ba, Miao Hao, He Huang, Junmei Hou, Shichao Ge, Zhuzhen Zhang, Jun Yin, Ruiai Chu, Liang Hua Jiang, Fudi Wang, Kaixian Chen, Hong Liu*, and Hui Wang* . Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin. Cancer Res. 2011, 17, 7625-7633. (IF=7.837)

15. Jiang Wang, Shengbin Zhou, Daizong Lin, Xiao Ding, Hualiang Jiang and Hong Liu*. Highly diastereo- and enantioselective synthesis of syn-β-substituted tryptophans via asymmetric Michael addition of a chiral equivalent of nucleophilic Glycine and sulfonylindoles. Chem. Commun. 2011, 47, 8355-8357. (IF=6.378)

16. Haifeng Sun, He Huang, Dengyou Zhang, Enguang Feng, Wangke Qian, Lei Zhang, Kaixian Chen and Hong Liu*. Synthesis of 4-Aryl-2(5H)-furanones by Gold(I)-Catalyzed Intramolecular Annulation. Adv. Synth. Catal. 2011, 353, 1413-1419. (IF=5.535)

17. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang and Hong Liu*. An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization. Adv. Synth. Catal. 2011, 353, 1429-1437. (IF=5.535)

18. Diliang Guo, Tao Chen, Deju Ye, Jinyi Xu, Hualiang Jiang, Kaixian Chen, Hui Wang*, and Hong Liu*. 细胞Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria. Org. Lett. 2011, 13, 2884-2887. (IF=6.142)

19. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang and Hong Liu*. Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles. Green Chem. 2011, 3, 397-405. (IF=6.828)

20. Jingui Ma, He Huang, Ling-hua Meng, 硅meng Chen, Yi Chen, Xian-liang Xin, Li-ping Lin , Hong Liu*, Jian Ding,* PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo Breast Cancer Research and Treatment. 2011, 130, 85-96. (IF=4.564)

21. Jing Deng , Enguang Feng, Sheng Ma, Yan Zhang, Xiaofeng Liu, Honglin Li*, Huang Huang, Jin Zhu, Weiliang Zhu, Xu Shen, Liyan Miao*, Hong Liu, Hualiang Jiang, Jian Li*. Design and Synthesis of First-in-Class Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases? Journal of Medicinal 化学2011, 54, 4508-4522. (IF=5.614)

22. Yu Zhou, Chunyi Jiang, Yaping Zhang, Zhongjie Liang, Wenfeng Liu, Liefeng Wang, Cheng Luo, Tingting Zhong, Yi Sun, Linxiang Zhao, Xin Xie, Hualiang Jiang, Naiming Zhou,* Dongxiang Liu* and Hong Liu*. Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors. Journal of Medicinal 化学 2010, 53, 5449-5466. (IF=5.614)

23. Yu Zhou,Yun Zhai, Jian Li, Deju Ye, Hualiang Jiang and Hong Liu.* Metal-free Tandem Reaction in H₂O: An Efficient and Regioselective Synthesis of 3-Hydroxyisoindolin-1-ones. Green 化学. 2010, 12，1397-1404. (IF=6.828).

24. He Huang, Qin Chen，Xin Ku, Linghua Meng*, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding , Hong Liu.* A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα 催化 activity. Journal of Medicinal Chemistry 2010, 53, 3048-3064. (IF=5.614)

25. Yu Feng, Xiao Ding, Tao Chen, Lili Chen , Fang Liu, Xu Jia, Xiaomin Luo,Xu Shen, Kaixian Chen, Hualiang Jiang, Hui Wang*, Hong Liu*, Dongxiang Liu.* 设计, Synthesis and Interaction Study of Quinazoline-2(1H)-Thione Derivatives as Novel Bcl-xL Inhibitors. Journal of Medicinal Chemistry 2010, 53, 3465-3479. (IF=5.614)

柳红是中国药物科学、药物化学前沿领军科学家，为中国药物化学学科发展和跻身国际先进行列做出了重要贡献。——《文汇报》《青年报》《解放日报》评

柳红为推动中国新药发展作出了突出贡献。——上观新闻评

做科研，她认真严谨；做导师，她温和热情；做女人，她优雅知性。柳红将不同的角色演绎出别样的精彩。——《中国科学报》评