杨淑华，女。毕业于新加坡国立大学，博士学位，中国农业大学生物学院教授。

现任九三学社第十五届中央委员会农林专门委员会副主任、秘书长（兼）。

1994年7月－1998年6月，任南开大学助理研究员。

2002－2004年，在美国康奈尔大学植物生物系从事博士后研究。

2005年1月至今，中国农业大学生物学院植物系教授。

2018年11月29日，访问南开大学生命科学学院，做客学院“百年校庆活动——校友讲坛”，做题为“拟南芥耐低温的分子调控机制”的学术报告。

2023年6月，九三学社第十五届中央委员会农林专门委员会副主任、秘书长（兼）。

研究方向

植物响应低温胁迫的分子机制。

作为外界主要环境因子，温度影响植物的生长发育、植被的分布以及农作物的产量。我们实验室主要是通过分子生物学、遗传学和生物化学等手段，研究植物应答低温胁迫的信号转导途径、低温信号与植物激素信号之间的交互作用，以及低温信号与生物胁迫信号之间的交互作用等。

1.植物响应零下低温胁迫的分子调控研究

在植物抗冻性研究方面，我们建立了稳定的冻相关突变体的筛选体系。通过该体系，我们发现蛋白激酶CRPK1（Cold-responsive protein kinase 1）参与负向调控低温信号途径关键转录因子CBF依赖的信号转导。低温激活定位于细胞膜上的CRPK1，后者磷酸化细胞质中的14-3-3蛋白，诱导其进入细胞核中，与CBF1/3蛋白互作，介导CBF1/3蛋白的泛素化降解，从而负调控植物对低温的应答。该研究不仅揭示了低温信号从细胞膜传递到细胞核中的负调控机制，也阐明了CBF蛋白翻译后修饰的调控机制（Liu et al., 2017,摩尔 细胞）。而蛋白激酶OST1在植物低温应答中发挥重要的正向调控作用。OST1激酶活性被低温迅速诱导，激活状态的OST1将ICE1磷酸化，抑制ICE1的泛素化降解，从而正调控植物的抗冻性（Ding et al., 2015,Dev Cell）。

在低温信号和植物激素信号的交叉互作方面，我们发现催熟激素信号通路关键组分均参与低温应答。转录因子EIN3蛋白直接负调控低温调节基因CBF和细胞分裂素信号负调控因子A型ARR基因的表达，从而负调控拟南芥的抗冻性。该研究明确了乙烯在植物抗低温中的作用，同时也揭示乙烯和细胞分裂素信号之间交互作用的分子机制（Shi et al., 2012,Plant Cell）。另一个重要植物激素油菜素内信号通路关键的蛋白激酶BIN2和转录因子BZR1/BES1通过依赖和不依赖于CBF的方式调控下游一系列基因的表达，从而正向调节植物的抗冻能力（Li et al., 2017,摩尔 Plant）。利用CRISPR技术，构建了cbfs三缺失突变体，明确了CBFs在低温驯化中的关键作用及CBFs的靶基因，并为低温信号研究提供了理想的遗传材料 (Jia et al., 2016,New Phytol)。

2.植物响应零上低温胁迫的分子调控研究

我们的研究发现拟南芥防卫反应中起重要作用的抗病相关基因CHS1、RPP4/CHS2、CHS3和LSD1/CHS4参与不同温度下植物生长的稳态平衡调控 (Wang et al., 2013,Plant J;Wang et al., 2011,Plant J;Huang et al., 2010,Plant Physiol; Yang et al., 2010,Plant J; Huang et al., 2010,New Phytol)。研究揭示TIR-NB类蛋白CHS1通过与R蛋白SOC3互作，蛋白磷酸酶IBR5和伴侣蛋白HSP90分别与R蛋白CHS3和CHS2互作，调控R蛋白的活性，从而调控R介导的温度依赖的细胞死亡和防卫反应 (Zhang et al., 2016,New Phytol; Liu et al., 2015,PLoS Genet; Bao et al., 2014,New Phytol)。

研究发现拟南芥磷脂结合蛋白BON1在调控温度依赖的生长发育中是一个关键调控因子，BON1与两个类受体蛋白激酶BIR1和BAK1互作，可能通过BAK1对BIR1和BON1的磷酸化，作用于同一条信号通路，协同调控温度依赖的植物生长发育和防卫反应 (Wang et al., 2011,Plant J; Yang et al.,2007,Plant Physiol; Yang et al., 2006,Plant J; Yang and Hua, 2004,Plant Cell)。

论文

1.Liu Z, Jia Y, Ding Y, Shi Y, Zhang X, Li Z, Guo Y, Gong Z,Yang S*(2017) 等离子体 membrane CRPK1-mediated phosphorylation of 14-3-3 proteins induces their nuclear import to fine-tune CBF signaling during cold response.摩尔 Cell66: 117-128. (Previewed in the same issue of Mol Cell)

2.Li H#, Ye K#, Shi Y, Zhang X,Yang S*(2017) BZR1 positively regulates freezing tolerance via CBF-dependent and CBF-independent pathways in Arabidopsis.摩尔 Plant 10: 545-559. (#These authors contributed equally) (Spotlighted in the same issue of Mol Plant)

3.Zhang Z#, Li J#, pan Y#, Li J#, Zhou L#, Shi H#, Zeng Y#, Guo H, Yang S, Zheng W, Yu J, Sun X, Li G, Ding Y, Ma L, Shen S, Dai Ln, Zhang H,Yang S, Guo Y, Li Z* (2017) Natural variation in CTB4a enhances rice adaptation to cold habitats.Nat Commun8:14788. Doi: 10.1038/ncomms14788.

4.Zhang Y#, Wang Y#, Liu J, Ding Y, Wang S, Zhang X, Liu Y,Yang S*(2017) 温度dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3.New Phytol213:1330-1345.

5.Jia Y, Ding Y, Shi Y, Zhang X, Gong Z,Yang S*(2016) The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis.New Phytol212: 345-353. (Commentary in the same issue of New Phytol)

6.Huang X, Zhang X, Gong Z,Yang S, Shi Y* (2016) ABI4 represses the expression of type-A ARRs to inhibit seed germination in ArabidopsisPlant J89: 354-365.

7.Yu F, Lou L, Tian M, Li Q, Ding Y, Wu Y, Belda-Palazon B, Rodrigue P L,Yang S, Xie Q* (2016) ESCRT-I component VPS23A affects ABA signaling by recognizing ABA receptors for endosomal degradation.摩尔 Plant9: 1570-1582.

8.Ding Y, Li H, Zhang X, Xie Q, Gong Z,Yang S* (2015) OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis.Dev Cell 32: 278-289. (Previewed in the same issue of 摩尔 细胞)

9.Liu J#, Yang H#, Bao F, Ao K, Zhang X, Zhang Y,Yang S* (2015) IBR5 modulates 温度dependent, R protein CHS3-mediated defense responses in Arabidopsis.PLoS Genet11, e1005584. (#These authors contributed equally)

10.Kong L, Cheng J, Zhu Y, Ding Y, Meng J, Chen Z, Xie Q, Guo Y, Li J,Yang S, Gong Z* (2015) Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases.Nat Commun6: 8630. Doi: 10.1038/ncomms9630.

11.Ji H, Wang Y, Cloix C, Li K, Jenkin G, Wang S, Shang Z, Shi Y,Yang S, Li X* (2015) The Arabidopsis RCC1 family protein TCF1 regulates freezing tolerance and cold acclimation through modulating lignin biosynthesis.PLoS Genet11, e1005471.

12.Shi Y#, Ding Y#, Yang S* (2015) Cold signal transduction and its Interplay娱乐 with phytohormones during cold acclimation. Plant Cell Physiol56: 7-15. (#These authors contributed equally)

13.Bao F, Huang X, Zhu C, Zhang X, Li X, Yang S*(2014) Arabidopsis HSP90 protein modulates RPP4-mediated 温度dependent cell 死亡 and defense responses. New Phytol202: 1320-1334.

14.Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T, Xie D* (2014) Interaction between MYC2 and 乙烯 INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis. Plant 细胞26: 263-279.

15.Wang Y, Zhang Y, Wang Z, Zhang X,Yang S*(2013) A missense mutation in CHS1, a TIR-NB protein, induces chilling sensitivity in Arabidopsis. Plant J 75: 553-565.

16.Shi Y, Wang Z, Meng P, Tian S, Zhang X, Yang S* (2013) The glutamate carboxypeptidase AMP1 mediates ABA and abiotic 应力 responses in Arabidopsis. New Phytol 199: 135-150.

17.Guo L, Yang H, Zhang X, Yang S*(2013) Lipid transfer protein 3 as a target of MYB96 mediates freezing and drought stress in Arabidopsis. J Exp Bot64: 1755-1767.

18.Li J#, Mu J#, Bai J#, Fu F, Zou T, An F, Zhang J, Jing H, Wang Q, Yang S, 左姓 J* (2013) 百草枯 RESISTANT 1, a Golgi-localized putative transporter protein, is involved in intracellular transport of paraquat. Plant Physiol 162: 470-483. (#These authors contributed equally)

19.Shi Y#, Tian S#, Hou L, Huang X, Zhang X, Guo H, Yang S*(2012) 乙烯 signaling negatively regulates freezing tolerance by repressing expression of CBF and type-A ARR genes in Arabidopsis. Plant Cell24: 2578-2595. (#These authors contributed equally)

20.Wang Z#, Meng P#, Zhang X, Ren D,Yang S*(2011) BON1 interacts with the protein kinases BIR1 and BAK1 in modulation of 温度dependent plant growth and 细胞 死亡 in Arabidopsis.Plant J 67: 1081-1093. (#These authors contributed equally)

21.Huang X, Li J, Bao F, Zhang X,Yang S*(2010) A gain-of-函数 mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low 温度Plant Physiol154: 796-809.

22.Yang H, Shi Y, Liu J, Guo L, Zhang X,Yang S*(2010) A mutant CHS3 protein with TIR-NB-LRR-LIM domains modulates growth, cell 死亡 and freezing tolerance in a temperature-dependent manner in Arabidopsis.Plant J63: 283-296.

23.Huang X, Li Y, Zhang X, Zuo J,Yang S*(2010) The Arabidopsis LSD1 gene plays an important role in the regulation of low 温度dependent cell 死亡New Phytol 187: 301-312 (Cover story).

24.Liu D, Gong Q, Ma Y, Li P, Li J,Yang S, Yuan L, Yu Y, pan D, Xu F, Wang NN* (2010) cpSecA, a thylakoid protein translocase subunit, is essential for photosynthetic development in Arabidopsis.J Exp Bot 61: 1655-1669.

25.Huang X, Zhang X,Yang S*(2009) A novel chloroplast-localized protein EMB1303 is required for chloroplast development in Arabidopsis.Cell Res19: 1205-1216.

26.Gou M, Su N, Zheng J, Huai J, Wu G, Zhao J, He J, Tang D,Yang S, Wang G* (2009) An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis.Plant J 60: 757-770.

27.Li Y#,Yang S#, Yang H, Hua J* (2007) The TIR-NB-LRR gene SNC1 is regulated at the transcript level by multiple factors.Mol Plant Microbe Interact20: 1449-1456. (#These authors contributed equally)

28.Yang H,Yang S, Li Y, Hua J* (2007) The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell 死亡.Plant Physiol 145: 135-146.

29.Chai MF, Wei PC, Chen QJ, An R, Chen YM, Chen J,Yang S*, Wang XC* (2006) NADK3, a novel cytoplasmic source of NADPH, is required under conditions of oxidative stress and modulates abscisic acid responses in Arabidopsis.Plant J47: 665-674.

30.Yang S, Yang H, Grisafi P, Sanchatjate S, Fink GR, Sun Q, Hua J* (2006) The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis.Plant J 45: 166-179.

31.YangS, and Hua J* (2004) A haplotype-specific resistance gene regulated by BONZAI1 mediates 温度dependent growth control in Arabidopsis.Plant Cell16: 1060-1071.

32.Yang S*, Yu H, Xu Y, Goh CJ* (2003) Investigation of 细胞分裂素deficient phenotypes in Arabidopsis by ectopic expression of orchid DSCKX1.FEBS Lett 555: 291-296.

33.Yang S, Yu H, Goh CJ* (2003) Functional characterisation of a cytokinin oxidase gene DSCKX1 in 石斛属 orchid. Plant Mol Biol 51: 237-248.

34.Yang S, Yu H, Goh CJ* (2002) Isolation and characterization of the orchid 细胞分裂素 oxidase DSCKX1 助催化剂J Exp Bot 53: 1899-1907.

35.Yu H,Yang S, Goh CJ* (2002) Spatial and temporal expression of the orchid floral homeotic gene DOMADS1 is mediated by its upstream regulatory elements.Plant 摩尔 Biol49: 225-237.

36.Yu H,Yang S, Goh CJ* (2001) 农杆菌属mediated transformation of a 石斛属 orchid with the class 1 knox gene DOH1.Plant Cell Rep 20: 301-305.

37.Yu H,Yang S, Goh CJ* (2000) DOH1, a class 1 knox Gene, is required for maintenance of the basic plant 建筑 and floral transition in orchid.Plant Cell 12: 2143-2160.

38.丁杨林，施怡婷，杨淑华(2015)植物响应低温胁迫的分子机制研究。生命科学.27:398-405.

39.邓岩，王兴春，杨淑华，左建儒(2006) 细胞分裂素：代谢、信号转导、交叉反应与农艺性状改良. 植物学通报.23:478-498.

专著

Shi Y,Yang S*(2014) ABA regulation of the cold stress response in plants. In Zhang D (ed)Abscisic Acid: Metabolism, Transport and Signaling.Springer, pp337-363.

Yu H, Dhavale T,Yang S(2006) Molecular mechanisms of hormone functions in flowering In Teixeira da Silva JA (ed) Floriculture, Ornamental and Plant Biotechnology: Advances and Topical Issues, Ed 1 Vol 1 Global Science Books, London, UK, pp 25-32.

任勃，王兴春，冯健，杨淑华，左建儒(2012)细胞分裂素。植物激素作用的分子机理(许智宏，薛红卫主编)上海科学技术出版社

武维华，张蜀秋，袁明，张军，韩玉珍，李颖章，叶德，杨淑华，王学臣(2008)植物生理学(第二版)科学出版社.

近年主持国家自然科学基金重大研究计划、重点项目、面上项目、国家重点基础研究规划项目（“973”）子课题等科研项目。

任New Phytologist Editor、Plant \u0026 Cell Physiology Advisory Editor、《植物学报》副主编。

2023年8月31日，入选2023年中国科学院院士增选有效候选人名单。