黄永焯，男，博士，现任
中国科学院上海药物研究所研究员、博士生导师。
人物经历
2002年，于广州中医药大学获硕士学位。
2005-2010年，在美国
密歇根大学药学院从事药剂学研究。
2010年6月，获百人计划资助，进入中国科学院上海药物研究所工作。
研究方向
经皮新剂型与新技术：包括
化学药物/中药有效成分经皮新剂型与新技术，经皮疫苗给药研究。
生物技术药物输送系统研究：包括新型载体材料的制备，载体与大分子药物的相互作用，载体给药系统与生物屏障的相互作用，生物大分子黏膜给药研究，以及大分子药物靶向给药研究。
科研成果
主要从事生物技术
药物制剂专业研究。在蛋白、基因类大分子给药系统研究中取得系列研究成果。例如，使用透皮抗原实现
新型冠状病毒疫苗非注射接种的研究发表于 Angewandte Chem. Int. Ed.,并且被该刊选为新闻亮点报道。此外，该研究还受到US New and World Report及其他媒体的关注和报道。至今共发表学术论文19篇（SCI 13篇，EI 1篇），参写专著2部。
主要论文
[1]Tang，Yisi，Liang，Jianming，Wu，Aihua，Chen，Yingzhi，Zhao，Pengfei，Lin，Tingting，Zhang，Meng，Xu，Qin，Wang，Jianxin，Huang，Yongzhuo. Co-Delivery of Trichosanthin and Albendazole by Nano-Self-Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis (vol 9，pg 26648，2017). ACS APPLIED MATERIALS \u0026 INTERFACESnull. 2020，12(2): 3275-3275.
[2]Chen，Yingzhi，Zhang，Meng，Min，Kyoung Ah，Wang，Huiyuan，Shin，Meong Cheol，Li，Feng，Yang，
Victor C，Huang，Yongzhuo. Improved Protein
毒素 Delivery Based on ATTEMPTS Systems. CURRENT DRUG TARGETSnull. 2018，19(4): 380-392.
[3]Xu，Fan，Zhong，Huihai，Chang，Ya，Li，
越南盾dong，Jin，Hongyue，Zhang，Meng，Wang，Huiyuan，Jiang，Chen，Shen，Youqing，Huang，Yongzhuo. Targeting
死亡 receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites. BIOMATERIALS[J]. 2018，158: 56-73.
[4]Yongzhuo Huang. Dual-Targeting Biomimetic Delivery for Antiglioma via Remodeling Tumor Microenvironment and Directing Macrophage-Mediated Immunotherapy. Chemical Science. 2018，[5]Kang，Xuejia，Zheng，Zenin，Liu，Zehua，Wang，Huiyuan，Zhao，Yuge，Zhang，Wenyuan，Shi，Mingjie，He，Yang，Cao，Yang，Xu，Qin，Peng，Chengyuan，Huang，Yongzhuo. Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis. MOLECULAR PHARMACEUTICS[J]. 2018，15(4): 1618-1626.
[6]Li，
越南盾dong，Zhang，Meng，Xu，Fan，Chen，Yingzhi，Chen，Binfan，Chang，Ya，Zhong，Huihai，Jin，Hongyue，Huang，Yongzhuo. Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation. ACTA PHARMACEUTICA SINICA B[J]. 2018，8(1): 74-84.
[7]Yongzhuo Huang. Mannosylated Liposomal Codelivery of Dihydroartemisinin and Doxorubicin for Drug-Resistant Colon Cancer Therapy. Acta Pharmacologica Sinica. 2017，[8]Chen，Yingzhi，Zhang，Meng，Jin，Hongyue，Li，
越南盾dong，Xu，Fan，Wu，Aihua，Wang，Jinyu，Huang，Yongzhuo. Glioma Dual-Targeting Nanohybrid Protein
毒素 Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery. THERANOSTICS[J]. 2017，7(14): 3489-3503.
[9]Xu，Jiaojiao，Xu，Beihua，Tao，Jin，Yang，Yunxu，Hu，Ying，Huang，Yongzhuo. Microneedle-Assisted，DC-Targeted Codelivery of pTRP-2 and Adjuvant of
紫杉醇 for Transcutaneous Immunotherapy. SMALL[J]. 2017，13(28).
[10]Peng，Huige，Chen，Binfan，Huang，Wei，Tang，Yubo，Jiang，Yifan，Zhang，Wenyuan，Huang，Yongzhuo. Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat. NANO LETTERS[J]. 2017，17(12): 7684-7690
[11]Tan Jiao，Wang Huiyuan，Xu Fan. Poly-γ-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy.. 2017.
[12]Chen，Yingzhi，Zhang，Meng，Jin，Hongyue，Tang，Yisi，Wu，Aihua，Huang，Yongzhuo. Prodrug-Like，PEGylated Protein
毒素 Trichosanthin for Reversal of Chemoresistance. MOLECULAR PHARMACEUTICS[J]. 2017，14(5): 1429-1438.
[13]Chen，Yingzhi，Zhang，Meng，Jin，Hongyue，Tang，Yisi，Wang，Huiyuan，Xu，Qin，Li，Yaping，Li，Feng，Huang，Yongzhuo. Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature. BIOMATERIALS[J]. 2017，116: 57-68.
[14]Zhao，Pengfei，Yin，Weimin，Wu，Aihua，Tang，Yisi，Wang，Jinyu，
pan，Zhenzhen，Lin，Tingting，Zhang，Meng，Chen，Binfan，Duan，Yifei，Huang，Yongzhuo. Dual-Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug-Resistant Cancer Therapy. ADVANCED FUNCTIONAL MATERIALS[J]. 2017，27(44).
[15]Lin，Tingting，Zhao，Pengfei，Jiang，Yifan，Tang，Yisi，Jin，Hongyue，
pan，Zhenzhen，He，Huining，Yang，Victor C，Huang，Yongzhuo. Blood-Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy. ACS NANO[J]. 2016，10(11): 9999-10012.
[16]Yongzhuo Huang.
NU.CLEARtargeting TAT-PEG-Asp8-Doxorubicin Polymeric Nanoassembly for Overcoming Drug-resistant Colon Cancer. ACTAPHARMACOLOGICASINICA. 2016，[17]Cui，Yanna，Zhang，Meng，Zeng，Feng，Jin，Hongyue，Xu，Qin，Huang，Yongzhuo. Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy. ACS APPLIED MATERIALS \u0026 INTERFACES[J]. 2016，8(47): 32159-32169.
[18]Hu，Ying，Xu，Beihua，Xu，Jiaojiao，Shou，Dan，Liu，Ergang，Gao，Jianqing，Liang，Wenquan，Huang，Yongzhuo. Microneedle-assisted dendritic
细胞targeted nanoparticles for transcutaneous
脱氧核糖核酸 immunization.
均聚物 化学[J]. 2015，6(3): 373-379.
[19]Wang，Yaping，Lin，Tingting，Zhang，Wenyuan，Jiang，Yifan，Jin，Hongyue，He，Huining，Yang，
Victor C，Chen，Yi，Huang，Yongzhuo. A Prodrug-type，MMP-2-targeting Nanoprobe for Tumor Detection and Imaging. THERANOSTICS[J]. 2015，5(8): 787-795.
[20]Wang，Huiyuan，Jiang，Yifan，Peng，Huige，Chen，Yingzhi，Zhu，Peizhi，Huang，Yongzhuo. Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors. ADVANCED DRUG DELIVERY REVIEWSnull. 2015，81: 142-160.
[21]Liang，Jianming，Zeng，Feng，Zhang，Meng，
pan，Zhenzhen，Chen，Yingzhi，Zeng，Yuaner，Xu，Yong，Xu，Qin，Huang，Yongzhuo. Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer
细胞s. RSC ADVANCES[J]. 2015，5(54): 43733-43740.
[22]Wang，Huixin，Zhao，Yongxing，Wang，Huiyuan，Gong，Junbo，He，Huining，Shin，Meong Cheol，Yang，Victor C，Huang，Yongzhuo. Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer. JOURNAL OF CONTROLLED RELEASE[J]. 2014，192: 47-56.
[23]Jiang，Yifan，Lu，Junyan，Wang，Yaping，Zeng，Feng，Wang，Huiyuan，Peng，Huige，Huang，Min，Jiang，Hualiang，Luo，
成姓，Huang，Yongzhuo. Molecular-
动力学Simulation-Driven
设计 of a Protease-Responsive Probe for In-
vivo Tumor Imaging. ADVANCED MATERIALS[J]. 2014，26(48): 8174-8178.
[24]Tan，Jiao，Cheong，Heesun，Park，Yoon Shin，Kim，Hangun，Zhang，Meng，Moon，Cheol，Huang，Yongzhuo.
细胞Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs. CURRENT PHARMACEUTICAL BIOTECHNOLOGY[J]. 2014，15(3): 231-239.
[25]Wang，Zhao，Chen，Yingzhi，Liu，Ergang，Gong，Junbo，Shin，Meong Cheol，Huang，Yongzhuo. CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery. PROTEIN AND PEPTIDE LETTERS[J]. 2014，21(11): 1129-1136.
[26]Wang，Yaping，Jiang，Yifan，Zhang，Meng，Tan，Jiao，Liang，Jianming，Wang，Huixin，Li，Yaping，He，Huining，Yang，Victor C，Huang，Yongzhuo. Protease-Activatable Hybrid Nanoprobe for Tumor Imaging. ADVANCED FUNCTIONAL MATERIALS[J]. 2014，24(34): 5443-5453.
[27]Wang，Huiyuan，Li，Feng，Du，Chengan，Wang，Huixin，Mahato，Ram I，Huang，Yongzhuo. Doxorubicin and Lapatinib
组合 Nanomedicine for Treating Resistant Breast Cancer. MOLECULAR PHARMACEUTICS[J]. 2014，11(8): 2600-2611.
[28]Wang，Huiyuan，Wang，Huixin，Liang，Jianming，Jiang，Yifan，Guo，Qianqian，Peng，Huige，Xu，Qin，Huang，Yongzhuo.
细胞Penetrating Apoptotic Peptide/p53
脱氧核糖核酸 Nanocomplex as Adjuvant Therapy for Drug-Resistant Breast Cancer. MOLECULAR PHARMACEUTICS[J]. 2014，11(10): 3352-3360.
[29]Huang，Yongzhuo，Jiang，Yifan，Wang，Huiyuan，Wang，Jianxin，Shin，Meong Cheol，Byun，Youngro，He，Huining，Liang，Yanqin，Yang，Victor C. Curb challenges of the "Trojan Horse" approach: Smart strategies in achieving effective yet safe
细胞penetrating peptide-based drug delivery. ADVANCED DRUG DELIVERY REVIEWSnull. 2013，65(10): 1299-1315.
[30]Yan，Lu，Wang，Huiyuan，Jiang，Yifan，Liu，Jinhua，Wang，Zhao，Yang，Yongxin，Huang，Shengwu，Huang，Yongzhuo.
细胞Penetrating Peptide-Modified PLGA Nanoparticles for Enhanced Nose-to-Brain Macromolecular Delivery. MACROMOLECULAR RESEARCH[J]. 2013，21(4): 435-441.
[31]Wang，Ye，Liu，Ergang，Sun，Xiaoyi，Huang，Pengyu，Long，Hao，Wang，Hua，Yu，Xin，Zheng，Caihong，Huang，Yongzhuo. Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs.
均聚物 化学[J]. 2013，4(10): 2958-2962.
[32]Sun，Yajuan，Dong，Weibing，Wang，Huiyuan，Huang，Yongzhuo，Gu，Huike，Yang，Victor C，Gong，Junbo. Template synthesis of PMAA@
几丁聚糖 hollow nanorods for docetaxel delivery.
均聚物 化学[J]. 2013，4(8): 2489-2495.
[33]Wang，Huiyuan，Guo，Qianqian，Jiang，Yifan，Liu，Ergang，Zhao，Yongxing，Wang，Huixin，Li，Yaping，Huang，Yongzhuo. Co-delivery of
细胞permeable Chimeric Apoptosis AVPIR(8) Peptide/p53
脱氧核糖核酸 for
鸡尾酒 Therapy. ADVANCED FUNCTIONAL MATERIALS[J]. 2013，23(48): 6068-6075.
[34]Guo，Qianqian，Wang，Huiyuan，Zhao，Yongxing，Wang，Huixin，Zeng，Feng，Hua，Haiying，Xu，Qin，Huang，Yongzhuo.
细胞penetrating albumin conjugates for enhanced doxorubicin delivery.
均聚物 化学[J]. 2013，4(17): 4584-4587.
[35]Liu，Jinhua，Zhao，Yongxing，Guo，Qianqian，Wang，Zhao，Wang，Huiyuan，Yang，Yongxin，Huang，Yongzhuo. TAT-modified nanosilver for combating multidrug-resistant cancer. BIOMATERIALS[J]. 2012，33(26): 6155-6161.
[36]Wang，Shuo，Wang，Hua，Liang，Wenquan，Huang，Yongzhuo. An injectable hybrid nanoparticle-in-oil-in-
H₂O submicron emulsion for improved delivery of poorly soluble drugs. NANOSCALE RESEARCH LETTERS[J]. 2012，7(1): 219-219.
[37]Yang，Yongxin，Jiang，Yifan，Wang，Zhao，Liu，Jinhua，Yan，Lu，Ye，Junxiao，Huang，Yongzhuo. Skin-permeable quaternary nanoparticles with layer-by-layer structure enabling improved gene delivery. JOURNAL OF MATERIALS
化学[J]. 2012，22(19): 10029-10034.
[38]Yongzhuo Huang. In
vivo delivery of cell permeable antisense-HIF1a-oligonucleotide to adipose tissue reduces adiposity in obese
鼠科 Journal of Controlled Release. 2012，[39]Yongzhuo Huang. Magnetic nanoparticles for brain tumors imaging.. Current Pharmaceutical Biotechnology. 2012，[40]Yongzhuo Huang. Multidisciplinary drug delivery system for targeting tumor and its acidic microenvironment. Journal of Controlled Release. 2012，[41]Huang，Yongzhuo，Rao，Yuefeng，Chen，Jinliang，Yang，Victor C，Liang，Wenquan. Polysorbate cationic synthetic vesicle for gene delivery. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A[J]. 2011，96A(3): 513-519.
[42]Yang，Yongxin，Gao，Yu，Chen，Lingli，Huang，Yongzhuo，Li，Yaping. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS[J]. 2011，405(1-2): 188-195.
[43]He，Huining，David，Allan E，Zhang，Jian，Park，Yoon Shin，Wang，Jianxin，Huang，Yongzhuo，Wang，Jingkang，Yang，
Victor C. Low molecular weight protamine/
胰岛素 formulation with potential to attenuate protamine-masqueraded insulin allergy. MACROMOLECULAR RESEARCHnull. 2011，19(12): 1224-1226.
[44]Dong，Siyu，Wang，Shuo，Zheng，Caihong，Liang，Wenquan，Huang，Yongzhuo. An in situ-forming，
固体 lipid/PLGA hybrid implant for long-acting antipsychotics. SOFT MATTER[J]. 2011，7(12): 5873-5878.
[45]Zheng，Xiaoling，Huang，Yongzhuo，Zheng，Caihong，Dong，Siyu，Liang，Wenquan. Alginate-
几丁聚糖PLGA Composite Microspheres Enabling Single-Shot
肝炎 B Vaccination. AAPS JOURNAL[J]. 2010，12(4): 519-524.
[46]Huang，Yongzhuo，Park，Yoon Shin，Moon，Cheol，David，Allan E，Chung，Hee Sun，Yang，
Victor C. Synthetic Skin-Permeable Proteins Enabling Needleless Immunization. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2010，49(15): 2724-2727.
[47]Huang，Yongzhuo，Park，Yoon Shin，Wang，Jianxin，Moon，Cheol，Kwon，Young Min，Chung，Hee Sun，Park，Yoon Jeong，Yang，Victor C. ATTEMPTS System: A Macromolecular Prodrug Strategy for Cancer Drug Delivery. CURRENT PHARMACEUTICAL DESIGNnull. 2010，16(21): 2369-2376.
[48]Yoon Shin Park，Yongzhuo Huang，Yoon Jeong Park，Allan E. David，Lindsay White，Huining He，Hee Sun Chung，Victor C. Yang. Specific down regulation of 3T3-L1 adipocyte differentiation by
细胞permeable antisense HIF1α-oligonucleotide. JOURNAL OF CONTROLLED RELEASE. 2010，144(1): 82-90.
[49]Yu，Faquan，Zhang，Lei，Huang，Yongzhuo，Sun，Kai，David，Allan E，Yang，Victor C. The magnetophoretic mobility and superparamagnetism of core-shell iron oxide nanoparticles with dual targeting and imaging functionality. BIOMATERIALS[J]. 2010，31(22): 5842-5848.
[50]Huang，Yongzhuo，Yu，Faquan，Park，YoonShin，Wang，Jianxin，Shin，MeongCheol，Chung，Hee Sun，Yang，Victor C. Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery. BIOMATERIALS[J]. 2010，31(34): 9086-9091.
[51]Yu，Faquan，Huang，Yongzhuo，Cole，Adam J，Yang，Victor C. The artificial peroxidase activity of magnetic iron
氧化物 nanoparticles and its application to glucose detection. BIOMATERIALS[J]. 2009，30(27): 4716-4722.
参考资料：
社会职务
3.世中联经皮给药专业委员会常务理事
6.中药新药与临床药理编委
7.药学学报（中英文版）青年编委
8.中国现代应用药学编委
9.Heliyon编委
资料来源：
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