王峰博士,男,
天津医科大学医学教授,细胞生物学专业博士生导师。主要致力于致力于研究端粒与细胞衰老的关系以及端粒酶在肿瘤发生发展中的关键作用。
个人资料
2003年毕业于
曲阜师范大学生命科学院,生命科学专业,2008年在武汉大学获得生物物理学博士学位。后在美国Cincinnati University进行博士后研究。2014年回国任天津医科大学基础医学院教授,入选
天津市"青年千人"计划,天津市“131”创新型人才,独立支配经费295万元。王峰教授,致力于研究端粒与细胞衰老的关系以及端粒酶在肿瘤发生发展中的关键作用。相关工作在PNAS,
emboJ以及Cell Reports等科研杂志发表。
工作经历
2014年6月~今天津医科大学医用生物学教研室教授
研究方向
王峰老师课题组主要研究方向包括:
2)端粒DNA高级结构形成对复制性衰老的影响;
3)环境污染引发DNA损伤以及复制性衰老的作用机制;
4)端粒长度缩短对智力发育以及认知水平的影响及机制。
发表文章
Wang F*, Steward J, Carolyn PM. (2014) Human CST Abundance Determines Recovery from Diverse Forms of DNA Damage and Replication Stress. Cell Cycle; 15;13(22):3488-3498
Kasbek,C., Wang,F ., Price,C.M. (2013) Human TEN1 maintains telomere integrity and functions in genome-wide replication restart. Journal of Biological
化学; 288(42): 30139-50
Wang, F ., Tang,
ML, Zeng, Z.X., Wu. R.Y., Xue, Y., Hao, Y.H., Pang, D.W., Zhao, Y., Tan, Z. (2012) Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells. Proc Natl Acad Sci U S A 109: 20413-20418
Wang, F ., Stewart, J.A ., Kasbek, C., Zhao, Y., Wright, W.E., Price, C.M. (2012) Human CST has independent functions during telomere duplex replication and C-strand fill-in. Cell Rep. 2:1096-1103
Stewart, J.A., Wang, F., Chaiken, M.F., Kasbek, C., Chastain, P.D., Wright, W.E., Price, C.M. (2012) Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J. 31:3537-3549
Stewart, J.A., Chaiken, M.F., Wang, F., Price, C.M. (2012) Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation. Mutation Research. 730:12-19
Wang, F., Zhao, Y., Hao, Y., Tan, Z. (2008) Identification of low-abundance alternatively spliced mRNA variants by exon exclusive reverse transcriptase polymerase chain reaction. Anal Biochem 383: 307-310
kan, ZY., Lin, Y., Wang, F.,
壮族, X.Y., Zhao, Y., Pang, D.W., Hao, Y.H., Tan, Z. (2007) G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition. Nucleic Acids. Res. 35: 3646-3653