李大伟，男，1964年10月出生，河南人，中国农业大学博士导师。

主要从事分子植物病毒学的基础理论及应用基础研究。授权专利“甜菜黑色焦枯病毒作为外源基因的表达载体”。

1985.7--1988.8，河南农业大学植保系助教。

1995.12--1997.11，中国科学院遗传所博士后。

1997.12--2002.12，中国农业大学农业生物技术国家重点实验室副教授。

1999.11--2002.8，美国University of Colorado Health Sciences Center生化与分子遗传学系博士后。

2002.12--今，中国农业大学生物学院微生物学与免疫学系及农业生物技术国家重点实验室教授、博士生导师。

2007.3--2007.9，美国俄勒冈大学 State University的James Carrington教授实验室高级研究学者。

2006.5-今，中国农业生物技术学会常务理事。

2005.4-今，中国农业生物技术学会微生物技术分会副会长。

2004.4-2009.12，Chinese Journal of Agricultural Biotechnology(英国CABI集团出版)特邀编辑。

研究方向

主要从事分子植物病毒学的基础理论及应用基础研究，研究内容包括：

（1）大麦条纹花叶病毒（BSMV）对不同寄主植物致病性差异的分子机制以及抗BSMV新基因的功能分析；建立并完善BSMV诱导的基因沉默（BSMV-based VIGS）载体系统，为小麦、大麦、玉米、高粱和谷子等禾本科的基因功能分析提供高效、便捷的工具。

（2）以甜菜黑色焦枯病毒（BBSV）和烟草坏死病毒A（TNV-A）等病毒为研究对象，分析病毒和寄主植物的相互作用以及互作过程中的一些重要蛋白质的晶体结构解析。

（3）抗病毒转基因作物新品种(系)的培育。

论文

Gerda Szakonyi, Joel M Guthridge,Dawei Li, Young Kendra, Michael V Holers, Xiaojiang S Chen, 2001, Structure of complement receptor 2 in complex with its C3d ligand,Science, 292: 1725-1728.

Dawei Li, Rui Zhao, Wayne Lilyestrom, Dahai Gai, Rongguang Zhang, DeCaprio James, Ellen Fanning, Gerda Szakonyi, Xiaojiang S Chen, 2003, Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen,Nature, 423: 512-518.

Dahai Gai,Dawei Li, Carla V Finkielstein, Robert D Ott, Poonam Taneja, Ellen Fanning, Xiaojiang S Chen, 2004, Insights into the oligomeric states, conformational changes and helicase activities of SV40 large tumor antigen,Journal of Biological 化学, 279: 38952-38959.

Dahai Gai, Rui Zhao,Dawei Li, Carla V Finkielstein, Xiaojiang S Chen, 2004, Mechanisms of conformational change for a replicative hexameric helicase of SV40 large T antigen,Cell, 119: 47-60.

Lihua Guo, Yunhe Cao,Dawei Li,Shengniao Niu, Zhunan Cai, Chenggui Han, Yafeng Zhai, Jialin Yu, 2005, Analysis of 核苷酸 sequences and multimeric forms of a novel satellite 核糖核酸 associated with Beet 黑色 Scorch 病毒,Journal of Virology, 79: 3664-3674 .

Yunhe Cao, Xuefeng Yuan, Xiaoxing Wang, Lihua Guo, Zhunan Cai, Chenggui Han,Dawei Li*, Jialin Yu, 2006, Effect on viral pathogenicity of Beet black scorch virus coat protein,Progress in Biochemistry and Biophysics, 33: 127-134.

Zhaohui Wang, Shuoguo Fang, Zhiyan Zhang, Chenggui Han,Dawei Li*, Jialin Yu, 2006, Development of an ID-ELISA for the detection of Rice 黑色streaked dwarf 病毒 in plants,Journal of Virological Methods, 134: 61-65.

Xuefeng Yuan, Yunhe Cao, Dehui Xi, Lihua Guo, Chenggui Han,Dawei Li*, Yafeng Zhai, Jialin Yu, 2006, Analysis of the subgenomic RNAs and the small ORFs of Beet 黑色 Scorch 病毒 by in vitro transcripts,Journal of General Virology, 78: 3077-3086.

Dehui Xi, Jiang Li, Chenggui Han,Dawei Li*, Jialin Yu, Xueping Zhou, 2008, Complete 核苷酸 sequence of a new strain of Tobacco necrosis 病毒 A infecting soybean in China and infectivity of its full-length cDNA clone,Virus Genes, 36: 259-266.

Montgomery T A, Howell M, Cuperus J T,Dawei Li, Alexander A, Chapman E J, Fahlgren N, Allen E, and James C Carrington, 2008, Specificity of ARGONAUTE7-miR390 Interaction and Dual Functionality of ARGONAUTE7-miR390 Complexes inTAS3 Trans-Acting siRNA Formation,Cell, 133: 128-141.

Yongliang Zhang, Jiang Li, Heng Pu, Jin Jin, Xiaofeng Zhang, Mingkuan Chen, Bin Wang, Chenggui Han, Jialin Yu,Dawei Li*,2010, Development of Tobacco necrosis 病毒 A as a vector for efficient and stable expression of FMDV VP1 peptides,植物界 Biotechnology Journal, 8(4): 506-523.

Bo Zhou, Yongliang Zhang, Xianbing Wang, Jiangli Dong, Bin Wang, Chenggui Han, Jialin Yu,Dawei Li*, 2010, Oral administration of plant-based 轮状病毒 VP6 induces antigen-specific IgAs, IgGs and passive protection in mice,Vaccine, 28(37): 6021-6027.

Yanhong Han, Haiying Xiang, Qian Wang, Yuanyuan Li, Wenqi Wu, Chenggui Han,Dawei Li, Jialin Yu, 2010, Ring structure amino acids affect the suppressor activity ofMelon 蚜虫borne yellows virusP0 protein.Virology, 406(1): 21-27.

Yanjing Zhang, Xiaofeng Zhang, Shaofang Niu, Chenggui Han, Jialin Yu,Dawei Li*, 2011, Nuclear localization ofBeet 黑色 Scorch viruscapsid protein and its interaction with importin α,病毒 Research, 155(1): 307-315.

Cheng Yuan, Cui Li, Lijie Yan, Andrew O Jackson, Zhiyong Liu, Chenggui Han, Jialin Yu,Dawei Li, 2011, A high throughputBarley stripe mosaic virusvector for virus induced gene silencing in monocots and dicots,PLoS ONE, 6: e26468.

Yu Cui, Mi Yeon Lee, Naxin Huo, Jennifer Bragg, Lijie Yan, Cheng Yuan, Cui Li, Sara J. Holditch, Jingzhong Xie, Ming-Cheng Luo,Dawei Li, Jialin Yu, Joel Martin, Wendy Schackwitz, Yong-Qiang Gu, John P. Vogel, Andrew O. Jackson, Zhiyong Liu1, and David F. Garvin, 2012, Fine mapping of theBarley stripe mosaic virusresistance geneBsr1in the model grassBrachypodium distachyon,PLoS ONE, 7(6): e38333.

Xiuchun Zhang, Xiaofeng Zhang, Jasleen Singh,Dawei Li, and Feng Qu, 2012, 温度dependent survival ofTurnip crinkle 病毒infected Arabidopsis plants relies on an 核糖核酸 silencing-based defense that requires DCL2, AGO2, and HEN1,Journal of Virology, 86: 6847-6854.

Xiaohui Wang, Yanjing Zhang, Jin Xu, Lindan Shi, Huiyan Fan,Daiwei Li, Chenggui Han, Jialin Yu, 2012, The R-rich motif of Beet 黑色 Scorch 病毒 P7a movement protein is important for the nuclear localization, nucleolar targeting and viral infectivity,Virus Research, 167(2): 207-218.

Deshui Liu, Lindan Shi, Chenggui Han, Jialin Yu, Dawei Li, Yongliang Zhang 2012, Validation of reference genes for gene expression studies in 病毒infectedNicotiana benthamianausing quantitative Real-时间 PCR.PLoS ONE, 7: e46451.

Jin Xu, Xianbing Wang, Lindan Shi, Yuan Zhou,Dawei Li, Chenggui Han, Ziding Zhang, Jialin Yu, 2012, Two distinct sites are essential for virulent infection and support of variant satellite 核糖核酸 replication in spontaneousBeet 黑色 Scorch virusvariants.Journal of General Virology, 93(12): 2718-2728.

Mi Yeon Lee, Lijie Yan, Florien A. Gorter, Brian Y.T. Kim, Yu Cui, Yue Hu, Cheng Yuan, Jessica Grindheim, Uma Ganesan, Zhiyong Liu, Chenggui Han, Jialin Yu,Dawei Li*and Andrew O. Jackson*, 2012,短柄草属 distachyonBd3-1 resistance is elicited by theBarley stripe mosaic virusTriple Gene Block 1 movement protein.Journal of General Virology, 93(12): 2729-2739. (Cover story)

Thi-Sau Dinh, Cuiji Zhou, Xiuling Cao, Chenggui Han, Jialin Yu,Dawei Li, Yongliang Zhang,2012. The complete genome sequence ofSouthern rice 黑色streaked dwarf virusisolated from Vietnam.The 植物界 病理学 Journal, 28(4):428-432.

Xiuling Cao, Yingui Lu, Dianping Di, Zhiyan Zhang, He Liu, Lanzhi Tian, Aihong Zhang,Yanjing Zhang, Lindan Shi, Bihong Guo, Jin Xu, Xifei Duan, Xianbing Wang, Chenggui Han, Hongqin Miao*, Jialin Yu*,Dawei Li*,2013, Enhanced 病毒 resistance in transgenic maize expressing a ds核糖核酸specific endoribonuclease gene fromE. coli.PLoS ONE, 8(4): e60829.

Deshui Liu, Lindan Shi, Chenggui Han, Jialin Yu, Dawei Li, Yongliang Zhang 2012, Validation of reference genes for gene expression studies in 病毒infectedNicotiana benthamianausing quantitative Real-时间 PCR.PLoS ONE, 7: e46451.

专利情况

授权专利：“甜菜黑色焦枯病毒作为外源基因的表达载体”（ZL02155378.5）