陈育新，江苏普莱医药生物技术有限公司董事长，长春普莱医药生物技术有限公司执行董事，吉林大学分子酶学工程教育部重点实验室，教授、博士生导师、学术带头人。

· 2014年，获得安永会计师事务所复旦大学“中国最具潜力种子企业奖”

· 2014年，获得吉林省自然科学学术成果二等奖

项目：螺旋型抗菌肽的从头设计及作用机理研究

获奖人：陈育新、黄宜兵、刘 煜、黄金丰、李桂荣、何丽艳、翟乃翠、赵连静

编号：20142038

· 2014年，获得中华全国归国华侨联合会“第五届中国侨界创新成果贡献奖”

· 2014年，获得江阴市国家高新区“科技领军型团队”

· 2013年，获得吉林省“第四批拔尖创新人才第二层次人选”

· 2013年，获得长春市人民政府“中国政府友谊奖”

· 2013年，获得江阴市国家高新区“科技领军型团队”

· 2013年。获得江阴市国家高新区“海归创业先锋”

· 2012年，获得吉林省科技进步三等奖

项目：细胞膜活性多肽抗菌及抗癌活性及作用机理研究

获奖人：陈育新、黄宜兵、刘煜、黄金丰、王笑非、王红叶

编号：2012J30075

· 2012年，获得长春市“第五批有突出贡献专家”称号

· 2012年，获得长春市“优秀外国专家”称号

· 2012年，获得长春市“五四”青年奖章

· 2012年，获得江阴市国家高新区“科技领军型团队”

· 2011年，获得国家人社部“留学人员科技创新创业项目择优资助”

· 2011年，入选吉林省“百千万”人才工程

· 2011年，获得吉林省人民政府人才开发基金

· 2011年，获得长春市“优秀外资企业家”称号

· 2011年，入选江苏省“333”人才工程第三层次计划

2011年，获得江阴市经济开发区“科技领军型团队”

· 2010年，获得人社部“留学人员科技创新创业项目择优资助”

· 2010年，入选人社部“留学人员回国创业启动支持计划”

· 2010年，入选江苏省“企业博士聚集计划”

· 2010年，享受长春市“政府特殊津贴”

· 2010年，获得江阴市经济开发区“科技领军型团队”

· 2009年12月，获得国务院侨办第二届“百名华人华侨专业人士杰出创业奖”

· 2009年12月，获得国务院侨办首批“重点华人华侨创业团队”

· 2008年12月，项目获得ChinaBio风投高峰论坛“最具投资潜力企业奖”

· 2008年，获得无锡市“530”计划项目

· 2007年，获得吉林省“杰出青年基金”

· 2007年，获得长春市高新区“科技创业先进个人”

· 2006年，获得长春市高新区“科技创业优秀奖”

· 2004 年，获得加拿大阿尔伯塔大学“J. Gordin Kaplan Graduate Student Award”

· 1999 年，获得加拿大阿尔伯塔大学“University of Alberta Ph.D. Scholarship”

2014年无锡市330高层次领军团队计划

300万元

题目：基于抗菌肽的靶向抗肿瘤纳米药物研发与产业化

起止时间：2015.3-2018.2

2014年吉林省科技厅重大科技攻关项目（项目负责人）

50万元

题目：1.1新药抗菌肽滴眼液筛选研究与开发

编号：20140203010YY 起止时间：2014.1-2016.12

2014年国家自然科学基金面上项目（项目负责人）

75万元

题目：膜活性肽对不同类型细胞膜亲和机制的研究

编号：81373455 起止时间：2014.1-2017.12

2013年吉林大学基本科研业务费项目─平台基地建设项目

5万元

题目：抗肿瘤Miniprotein的设计及机理研究

起止时间：2013.1-2014.12

2013年吉林大学发明专利种子基金

0.5万元

题目：提高多肽固相合成效率的二甲苯溶剂配方及应用

专利号：ZL2010101851296 2013年第七批138号

2012年国家科学技术部“重大新药创制”科技重大专项“十二五”项目

147.93万

题目：抗耐药菌的抗菌肽候选药物研究

编号：2012ZX09103101-065 起止时间：2012.1-2015.12

2012年吉林省新型抗耐药菌多肽药物研究创新团队

20万元

题目：新型抗耐药菌多肽药物的设计及机理研究

编号：20121807 起止时间：2012.1-2014.12

2011年国家科技部“科技型中小企业技术创新基金”（成长型）

90万

题目：I类抗菌肽新药PL-5临床前研究

编号：11C26212214338 起止时间：2011.6-2013.6

2011年江苏省科技厅“江苏省科技型企业技术创新资金项目”

25万

题目：国家I类抗菌新药—抗菌肽临床前研究

编号：BC2011047 起止时间：2011.4-2014.3

2010年吉林省科学技术厅“双十”项目“重大科技攻关项目”

300万

题目：I类抗菌新药乐舒肽（Lysotide）临床前及I期临床研究

编号：10ZDGG006 起止时间：2010.1-2012.12

2010年长春市科学技术局“长春市国际科技合作计划”

20万

题目：I类抗菌新药—乐舒肽的临床前药物研究

编号：10GH03 起止时间：2010.6-2011.6

2010年吉林省自然科学基金（项目负责人）

5万元

题目：抗菌肽对原核生物细胞膜与真核生物细胞膜作用方式的比较研究

编号：201015103 起止时间：2010.1-2012.12

2010年吉林省青年基金（第一参加人）

5万元

题目：螺旋度对抗癌肽活性的贡献及其抗肿瘤作用机理的研究

编号：20100126 起止时间：2010.9-2012.9

2009年国家自然科学基金（主任基金）（项目负责人）

10万元

题目：多肽疏水性与带电性的变化对抗菌肽作用机理的影响

编号：30940016 起止时间：2010.1-2010.12

2009年吉林大学科学前沿与交叉学科创新项目（项目负责人）

5万元

题目：抗菌肽对口腔细菌的抗菌活性及机理研究

编号：200903095 起止时间：2010.1-2011.12

2008年教育部博士点基金新教师项目（项目负责人）

3.6万元

题目：疏水性对螺旋型抗菌肽生物活性的影响

编号：200801831064 起止时间：2009.1-2010.12

2008年国家自然科学基金（主任基金）（项目负责人）

9万元

题目：氨基酸取代与疏水性变化对提高螺旋型抗菌肽特异性及作用机理的研究

编号：30840029 起止时间：2009.1-2009.12

2007年吉林省杰出青年基金（项目负责人）

重点项目 10万元

题目：正电性氨基酸对提高螺旋型抗菌肽抗菌特异性及作用机理的研究

编号：20070111 起止年限：2008.1-2009.12

2007年吉林大学种子基金（项目负责人）

4万元

2007年吉林大学引进人才启动基金（项目负责人）

5万元

2007年吉林大学985人才引进计划（项目负责人）

50万元

· 肽类与蛋白类药物的从头设计与机理研究

· Irisin对血糖控制及肥胖调控的机理研究

· 人工模拟酶研究

· 高效液相色谱在蛋白质工程与酶学研究上的应用

· 国家中华人民共和国国家自然科学基金委员会同行评议专家

· 吉林省科技项目评审专家（医药领域）

· 2012年 丹麦自然科学基金委（The Danish Council for Independent Research | Natural Sciences）国际评审专家

· 2011年 南京理工大学 环境与生物学院 兼职教授

· 2009年 江南大学医药学院 客座教授

· 中国细胞生物学学会会员

· 中国生物物理学会会员

· 吉林省生物化学与分子生物学会会员

杂志编辑及编委会委员

· Medicine, Academic Editor

· Pharmacologia, Editorial Board Member

审稿人：

· International Journal of Analytical Chemistry

· Chemical Biology and Drug 设计

· Journal of Peptide Science

· Applied Microbiology and Biotechnology

· European Journal of Medicinal 化学

· Peptides

· Anti-Cancer Drugs

· 高等学校化学学报

· 生物化学与生物物理进展

· ScienceAsia

发表论文：（SCI收录）

1. Yi, T. H., Sun, S. Y. Huang, Y. B. and Chen, Y. X.* Prokaryotic expression and mechanism of action of a-helical antimicrobial peptide A20L using fusion tags, 现代生物出版集团 Biotechnol. 2015, 15, 69

2. Mai, X. T., Huang, J. F., Tan, J. J., Huang, Y. B. and Chen, Y. X.* Effects and mechanisms of the secondary structure on the antimicrobial activity and specificity of antimicrobial peptides, J. Pept. Sci. 2015, 21, 561-568

3. Zhao, J., Huang, Y. B., Liu, D. and Chen, Y. X.* Two hits are better than one: synergistic anticancer activity of α-helical peptides and doxorubicin/epirubicin, Oncotarget, 2015, 6, 1769-1778

4. Huang, Y. B., Feng, Q., Yan, Q. Y., Hao, X. Y. and Chen, Y. X.* Alpha-helical cationic anticancer peptides: a promising candidate of novel anticancer drugs, Mini-Rev. Med. Chem., 2015, 15, 73-81

5. Yi, T. H., Huang, Y. B. and Chen, Y. X.* Prokaryotic expression and antimicrobial mechanism of xpf-st7-derived α-helical peptides, J. Pept. Sci. 2015, 21, 46-52

6. Yi, T. H., Huang, Y. B. and Chen, Y. X.* Production of an antimicrobial peptide AN5-1 in Escherichia coli and its dual mechanisms against bacteria, Chem. Biol. Drug Des. 2015, 85, 598-607

7. Feng, Q., Huang, Y. B., Chen, M. X., Li, G. R. and Chen, Y. X.* 函数al synergy of a-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo, Eur. J. Clin. Microbiol. 2015, 34， 197-204

8. Li, G. R., Huang, Y. B., Feng, Q. and Chen, Y. X.* 色氨酸 as a probe to study the anticancer mechanism of action and specificity of α-helical anticancer peptides, Molecules 2014, 19, 12224-12241

9. Tan, J. J., Huang, J. F., Huang, Y. B. and Chen, Y. X.* Effects of single amino acid substitution on the biophysical properties and biological activities of an amphipathic a-helical antibacterial peptide against gram-negative bacteria, Molecules 2014, 19, 10803-10817

10. Huang, Y. B., He, L. Y., Li, G. R., Zhai, N. C., Jiang, H. Y., and Chen, Y. X.* Role of helicity of α-helical antimicrobial peptides to improve specificity, Protein Cell 2014, 5, 631-642

11. Huang Y., pan L., Zhao L., Mant C. T., Hodges R. S., Chen Y. X.*. Structure-guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomers Biomed. Chromatogr. 2014, 28, 511-517

12. Zhao, L. J., Huang, Y. B., Gao, S., Cui, Y., He, D., Wang, L., Chen, Y. X.* Comparison on effect of hydrophobicity on the antibacterial and antifungal activities of a-helical antimicrobial peptides, Sci. China Chem. 2013, 56, 1307-1314

赵连静，黄宜兵，高嵩，崔岩，贺丹，王丽，陈育新*，螺旋型抗菌肽的疏水性对抗细菌与抗真菌活性的影响比较 中国科学：化学， 2013，43，1041-1050

13. Liu, X. Y., Huang, Y. B., Cheng, M., pan, L., Si, Y. H., Li, G. R., Niu, Y. Q., Zhao, L. J., Zhao, J., Li, X., Chen, Y. X.*, and Yang, W. Screening and rational 设计 of hepatitis C 病毒 entry inhibitory peptides derived from GB virus A NS5A, J. Virol. 2013, 87, 1649-1657

14. 黄宜兵，翟乃翠，高贵，陈育新，净电荷对螺旋型抗癌肽生物活性的影响，高等学校化学学报，2012， 33，1252-1258

15. Huang, Y. B., He, L. Y., Jiang, H. Y., and Chen, Y. X.* Role of helicity on the anticancer mechanism of action of cationic-helical peptides, Int. J. 摩尔 Sci. 2012, 13, 6849-6862

16. Shan, Y. P., Huang, J. F., Tan, J. J., Gao, G., Liu, S. H., Wang, H. D., and Chen, Y. X.* The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy, Nanoscale 2012, 4, 1283-1286.

17. Li G.R., He L.Y., Liu X.Y., Liu A.P., Huang Y.B., Qiu C., Zhang X.Y., Xu J.Q., Yang W., Chen Y.X.* Rational 设计 of Peptides with Anti-HCV/HIV Activities and Enhanced Specificity , Chem. Biol. Drug Des. 2011, 78, 835-843

18. 越南盾, A., Lan, S., Huang, J. F., Wang, T., Zhao, T. Y., Xiao, L. H., Wang, W. W., Zheng, X., Liu, F. G., Gao, G., 金钟大, Y. X.*, Modifying FeO-functionalozed nanoparticles with N-halamine and their magnetic/antibacterial properties, Appl. Mater. Interfaces 2011, 3, 4228-4235

19. 越南盾, A., Lan, S., Huang, J. F., Wang, T., Zhao, T. Y., Wang, W. W., Xiao, L. H., Zheng, X., Liu, F. G., Gao, G., 金钟大, Y. X.*, Preparation of magnetically separableN-halamine nanocomposites for the improved antibacterial application, J. Colloid Interf. Sci. 2011, 364, 333-340

20. 越南盾, A., Huang, J. F., Lan, S., Wang, T., Xiao, L. H., Wang, W. W., Zhao, T. Y., Zheng, L., Liu, F. Q., Gao, G., 金钟大, Y. X.*, Synthesis of N-halamine-functionalized silica–polymer core–shell nanoparticles and their enhanced antibacterial activity, Nanotechnology 2011, 22, 295602

21. Huang, J. F., Hao, D. M., Chen, Y., Xu, Y. M., Tan, J. J., Huang, Y. B., Li, F., 金钟大, Y. X.*, Inhibitory effects and mechanisms of physiological conditions on the activity of enantiomeric forms of an α-helical antibacterial peptide against bacteria, Peptides 2011, 32,1488-1495

22. Huang, Y. B., Wang, X. F., Wang, H. Y., Liu, Y., 金钟大, Y. X.*, Studies on mechanism of action of anticancer peptides by modulation of hydrophobicity within a defined structural framework, 摩尔 Cancer Ther. 2011, 10，416-426

23. Huang, J. F., Xu, Y. M., Hao, D. M., Huang, Y. B., Chen, Y. X.*, A feasible method for designing of alpha-helical antimicrobial peptide with enhanced specificity, J. Nanjing Univ. (Natural Sciences), 2010, 46, 133-137

24. Huang, Y. B., Huang, J. F., Chen, Y. X.*, Alpha-Helical Cationic Antimicrobial Peptides: Relationships of Structure and Function, Protein Cell 2010, 1，143-152

25. Huang, J. F., Xu, Y. M., Hao, D. M., Huang, Y. B., Liu, Y., 金钟大, Y. X.*, Structure Guided De novo 设计 of Alpha-Helical Antimicrobial Peptide with Enhanced Specificity, Pure Appl. Chem. 2010, 82, 243-257

26. Chen, Y.* De novo design of a-helical antimicrobial peptides with enhanced therapeutic index, J. Biotechnol. 2008, 136S, S77

27. Chen, Y., Guarnieri, M. T., Vasil, A. I., Vasil, M. L., Mant, C. T. and Hodges, R. S. The role of peptide hydrophobicity in the mechanism of action of a-helical antimicrobial peptides, Antimicrob. Agents Chemother., 2007, 51, 1398-1406

28. Lewis, R. N. A. H., Liu, F., Krivanek, R., Rybar, P., Hianik, T., Flach, C. R., Mendelsohm, R., 金钟大, Y., Mant, C. T., Hodges, R. S. and McElhaney, R. N. Studies of the minimum hydrophobicity of a-helical peptides required to maintain a stable transmembrane association with phospholipid bilayer membranes Biochemistry 2007, 46, 1042-1054

29. 金钟大, Y., Mant, C. T. and Hodges, R. S. Preparative reversed-phase high-performance liquid chromatography collection efficiency for an antimicrobial peptide on columns of varying diameters (1mm to 9.4mm I.D.) J. Chromatogr. 2007, 1140, 112-120

30. 金钟大, Y., Vasil, A. I., Rehaume, L., Mant, C. T., Burns, J. L., Vasil, M. L., Hancock, R. E. W. and Hodges, R. S. Comparison of biophysical and biological properties of a-helical enantiomeric antimicrobial peptides, Chem. Biol. Drug Des., 2006, 67, 162-173

31. 金钟大, Y., Mant, C. T., Farmer, S., Vasil, M., Hancock, R. E. W. and Hodges, R. S. Rational 设计 of a-Helical Antimicrobial Peptides with Enhanced Activities and Specificity/Therapeutic Index, J. Biol. Chem., 2005, 280, 12316-12329

32. Hodges R. S., Chen, Y., Ziemba B., and Guarnieri M. The de novo设计 of antimicrobial peptides with broad spectrum activity and specificity between bacterial and human cell membranes, Biopolymers, 2005, 80,544-544

33. Chen, Y., Mehok, A. R., Mant, C. T. and Hodges, R. S. Optimum concentration of trifluoroactic acid (TFA) for reversed-phase chromatography of peptides revisited J. Chromatogr. 2004, 1043, 9-18

34. Chen, Y., Mant, C. T. and Hodges, R. S. Selectivity differences in the separation of amphipathic a-helical peptides during reversed-phase chromatography at pH 2.0 and pH 7.0: Effects of different packings, mobile phase conditions and 温度 J. Chromatogr. 2004, 1043, 99-111

35. Hodges, R. S., Chen, Y., Kopecky, E. and Mant, C. T. Monitoring the Hydrophilicity/Hydrophobicity of Amino Acid Side-chains in the Non-polar and Polar Faces of Amphipathic a-Helices by Reversed-Phase and Hydrophilic Interaction/Cation-Exchange Chromatography J. Chromatogr. 2004, 1043, 161-172

36. Popa, T. V., Mant, C. T., Chen, Y. and Hodges, R. S. Capillary zone electrophoresis of a-helical diastereomeric peptide pairs with anionic ion-pairing reagents J. Chromatogr. 2004, 1043, 113-122

37. Chen, Y., Mant, C. T. and Hodges, R. S. 温度 selectivity effects in reversed-phase chromatography due to conformation differences between helical and non-helical peptides J. Chromatogr. 2003, 1010, 45-61

38. Mant, C. T. Chen, Y. and Hodges, R. S. 温度 profiling of polypeptides in reversed-phase chromatography: I. Monitoring of dimerization and unfolding of amphipathic a-helical peptides J. Chromatogr. 2003, 1009, 29-43

39. Hartmann E., Chen, Y., Mant, C. T., Jungbauer, A. and Hodges, R. S. Comparison of reversed-phase chromatography and hydrophilic interaction/cation-exchange chromatography for the separation of amphipathic a-helical peptides with L- and D-amino acid substitutions in the hydrophilic face J. Chromatogr. 2003, 1009, 61-71

40. Chen, Y. and Hodges, R. S. Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures. Biopolymers 2003， 71，334-334

41. Chen, Y., Mant, C. T. and Hodges, R. S. Determination of 立体化学 stability coefficients of amino acid side-chains in an amphipathic a-helix J. Peptide Res. 2002, 59, 18-33

42. Chen, Y., Zhang, X., Chen, S., You, D., Wu, X., Yang, X. and Guan W. Kinetically controlled syntheses catalyzed by proteases in reverse micelles and separation of precursor dipeptides of RGD Enzyme Microb. Technol. 1999, 25, 310-315

43. Chen, Y., Zhang, X., Zheng, K., Chen, S., Wang, Q. and Wu, X. Protease-catalyzed synthesis of precursor dipeptides of RGD with reverse micelles Enzyme Microb. Technol. 1998, 23, 243-248

综述、专著章节和会议文章

1. Mant, C. T., Chen, Y., Yan, Z., Popa, T. V., Kovacs, J. M., Mills, J. B., Tripet, B. P. and Hodges, R. S. HPLC analysis and purification of peptides, In “Peptide Characterization and Application Protocols” Methods in 摩尔 Biol. Vol. 386 pp3-55 (Ed. G. B. Fields) Humana Press Inc. Totowa, NJ 2007

2. Chen, Y. and Hodges, R. S. Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures. In “ Peptide Revolution: Genomics, Proteomics and Therapeutics”, Proceedings of the Eighteenth American Peptide Symposium (M. Chorev and T. K. Sawyer, 电子数据系统), Kluwer Academic Publishers pp 151-152 (2004)

3. Chen, Y., Mant, C. T. and R. S. Hodges. The determination of helix stability coefficients using D-amino acid substitutions in the non-polar face of an amphipathic a-helical model peptide. In “ Peptide: The Wave of the Future”, Proceedings of the Second International/Seventeenth American Peptide Symposium (R. A. Houghton and M. Lebl, Eds.), Kluwer Academic Publishers pp 353-354 (2001)

4. Lee, D. L., Chen Y., Wagschal, K. C., McHenna, S. A., Harland, B., Mant, C. T. and Hodges, R. S. Effect of D-amino acid substitutions on amphipathic a-helical structure. In “ Peptides for the New Millennium”, Proceedings of the Sixteenth American Peptide Symposium (Barany, G. and Fields, G, Eds) Kluwer Academic Publishers pp 289-290 (1999)

发明专利：

中国发明专利: 止痒组合物及其在制备止痒剂中的应用

中国专利号: 201210568326.5

发明人: 陈育新，陈明侠，李杨，王勇，付强

国际发明专利: Antibiotic peptide and preparation method therefor and application therefor

国际专利号(PCT): PCT/CN2012/000079

发明人: Chen, Y.

中国发明专利: 一种抗菌肽及其制备方法和应用

中国专利号: 201110095737.2

发明人: 陈育新，陈明侠，黄宜兵，李杨，王勇，曲莉莉，王文仁

中国发明专利: 提高多肽固相合成效率的二甲苯溶剂配方及应用

中国专利号: 201010185129.6

发明人: 陈育新，毛世忠，黄宜兵，王笑非，潘玲

美国发明专利: Antimicrobial peptides and methods of use

专利号: 60/636,220

发明人: Chen, Y., Hodges, R. S., Vasil, M., Hancock, R. E. W. and Farmer, S.

国际发明专利: Antimicrobial peptides and methods of use

国际专利号(PCT): WO 2006/065977 A2

发明人: Chen, Y., Hodges, R. S., Vasil, M., Hancock, R. E. W. and Farmer, S.

中国发明专利: 抗菌肽及其使用方法

中国专利号: 200580047492.9

发明人: 罗伯特S. 霍金斯，陈育新，迈克尔 瓦兹，罗伯特 E. W. 汉考克，苏珊 W. 法莫

会议：

大会发言：

1. Chen, Y. Synergistic anticancer mechanism of α-helical peptides and doxorubicin/epirubicin. Presented at the 13 Chinese International Peptide Symposium, Jul. 2-4, Datong,China2014

2. Chen, Y. Screening and rational 设计 of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A. Presented at the “CAMPUS ASIA” Pilot Program, Winter Seminar on Life and Material Sciences in Okayama, Jan. 23-24, Okayama, Japan 2014

3. Chen, Y. Role of Hydrophobicity on Mechanism of Action of Anticancer Peptides. Presented at the 12 Chinese International Peptide Symposium, Jul. 26, Shenyang,China2012

4. Chen, Y. Mechanism of Action of a-helical anticancer peptides: apoptosis or necrosis. Presented at the 14th Korean-Chinese Regional Symposium of Biotechnology, Feb. 16-18, Incheon,Korea2012

Yi-bing Huang, li-yan He, Xu Bai*, Yu-xin Chen*. Improving Therapeutic Index of Alpha-Helical Antimicrobial Peptides by Introducing D-Amino Acids. 17International Biophysics congress \u0026 12 Chinese Biophisics Congress. Oct. 30-Nov. 3, 2011, Beijing,ChinaSponsored by Protein \u0026 Cell. S27-O4

Gui-rong Li, Li-yan He, Yi-bing Huang, Yu-xin Chen*. Modulation of Helicity and Hydrophobicity of Peptides to Improve Anti-HCV/HIV Activities and Specificity. 17 International Biophysics congress \u0026 12 Chinese Biophisics Congress. Oct. 30-Nov. 3, 2011, Beijing,ChinaSponsored by Protein \u0026 Cell. S27-O5

Chen, Y. Role of Hydrophobicity on Mechanism of Action of Anticancer Peptides. Presented at the BIT Life Sciences' 4th Annual Protein \u0026 Peptide Conference (PepCon 2011), Mar. 23-25, Beijing, China 2011 (大会发言及分会主席)

陈育新，抗菌肽的从头设计提高其抗菌特异性，抗菌肽开发与应用技术研讨会，深圳，2009.12.15-16

Chen, Y. De novo design of a-helical antimicrobial peptides with enhanced therapeutic index. Presented at the 13 International Biotechnology Symposium and Exhibition, Oct 12-17, 大连市,China2008

Chen, Y. Rational 设计 of a-Helical Antimicrobial Peptide with Enhanced Activities and Specificity. Presented at the 11 Chinese-Korean Regional Symposium on Biotechnology, Dalian,China2007

Chen, Y. Role of Peptide Hydrophobicity in the Mechanism of Action of 　　a-Helical Antimicrobial Peptides. The 6th Symposium on Frontiers in Protein Chemistry and Biotechnology, Changchun,China2007

Chen, Y. Role of Peptide Hydrophobicity in the Mechanism of Action of 　　a-Helical Antimicrobial Peptides. International Symposium on Channelopathy and New Strategies of Drug Discovery，October 29 – 30, 2007, Changchun, China

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Yu-xin Chen*

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陈育新，抗菌肽的从头设计提高其抗菌特异性，抗菌肽开发与应用技术研讨会，深圳，2009.12.15-16

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大会墙报：

1. Huang, Y.B., Chen, Y. Synergistic anticancer activity and mechanism of a-helical peptides and doxorubicin/epirubicin. Presented at the 13 Chinese International Peptide Symposium, Jul. 2-4, Datong,China2014

Yi-bing Huang, li-yan He, Xu Bai*, Yu-xin Chen*. Effect of Helicity of α-Helical Anticancer Peptides on Biological Activities, 17 International Biophysics congress \u0026 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein \u0026 Cell. P27-6

Jin-feng Huang, Yu-ping Shan, Juan-juan Tan, Gui Gao, hongda Wang and Yu-xin Chen. Force Events of Single Molecular Anticancer Peptide Interacting with HeLa Cell Membrane Recorded by Atomic Force Microscope. 17 International Biophysics congress \u0026 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein \u0026 Cell. P25-21

Xuan-thanh Mai, Juan-juan Tan, 碘化钠cui Zhai, Li-yan He, Yu-xin Chen* Effects of Secondary Structure on the Antimicrobial Activity and Specificity of Antimicrobial Peptides. 17 International Biophysics congress \u0026 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein \u0026 Cell. P 6-3

Nai-cui Zhai, Yi-bing Huang, and yuxin Chen* .Role of Net Charge on the Biological Activities of Alpha-Helical Anticancer Peptides. 17 International Biophysics congress \u0026 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein \u0026 Cell. P 6-2

Juan-juan Tan, Jinfeng Huang, Yi-bing Huang , Yu-xin Chen*. The Effects of Single Amino Acid Substitution on the Biophysical and Biological Properties of an Amphipathic α-Helical Antibacterial Peptide. 17 International Biophysics congress \u0026 12 Chinese Biophisics Congress. Beijing,China, 2011, Sponsored by Protein \u0026 Cell. P27-7

Chen, Y., Guarnieri, M. T., Vasil, A. I., Vasil, M. L., Mant, C. T. and Hodges, R. S. (2006) The role of peptide hydrophobicity in the mechanism of action of a-helical antimicrobial peptides. Presented at the Gordon Research Conference, Chemistry and Biology of Peptides, Ventura, CA

Hodges R. S., Chen, Y., Ziemba B., and Guarnieri M. (2005) The rational design of a-helical antimicrobial peptides. Presented at the Nineteenth American Peptide Symposium, 苯乙烯-丙烯腈共聚物 Diego, CA

Chen Y. and Hodges, R. S. (2004) Rational design of a-helical antimicrobial peptides with improved specificity. Presented at the Eighth Chinese International Peptide Symposium, Kunming,China

Chen, Y., Mant, C. T. and Hodges, R. S. (2003) Effect of column packing, mobile phase conditions and temperature on reversed-phase chromatography of amphipathic alpha-helical peptides at pH 2.0 and pH 7.0. Presented at the twenty-third International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, Florida

Chen, Y., Mehok, A. R., Mant, C. T. and Hodges, R. S. (2003) Trifluoroacetic acid revisited for reserved-phase chromatography of peptides. Presented at the twenty-third International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, Florida

Chen, Y. and Hodges, R. S. (2003) Effect of secondary structure on selectivity of reversed-phase chromatography for peptide separations at varying temperatures. Presented at the Eighteenth American Peptide Symposium, Boston, MA

Chen, Y., Hartmann, E. Mant C. T. and Hodges, R. S. (2002) Monitoring the hydrophilicity/ hydrophobicity of amino acid side-chains in the non-polar and polar faces of amphipathic a-helices by reversed-phase and mixed-mode hydrophilic interaction/ cation-exchange chromatography. Presented at the twenty-second International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Heidelberg,Germany

Chen, Y., Mant C. T. and Hodges, R. S. (2001) The determination of helix stability coefficients using D-amino acid substitutions in the non-polar face of an amphipathic a-helical model peptide. Presented at the Second International/Seventeenth American Peptide Symposium, San Diego, CA

Chen, Y., Lee, D. L., Mant, C. T. and Hodges, R. S. (2000) Monitoring the effect of D-amino acids on the structure of amphipathic a-helical peptides by reversed-phase chromatography. Presented at the nineteenth International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Delray Beach, Florida

Lee, D. L., Chen Y., Wagschal, K. C., McHenna, S. A., Harland, B., Mant, C. T. and Hodges, R. S. (1999) Effect of D-amino acid substitutions on amphipathic a-helical structure. Presented at the Sixteenth American Peptide Symposium, Minneapolis, Minnesota

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Yu-xin Chen*

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