白钢
南开大学教授
白钢于1990年毕业于沈阳药科大学,1993年赴日本留学,1998年获药学博士学位。2000年作为南开大学引进人才回国在生命科学学院任教,在2000年任微生物学系主任,2004年任生命科学学院副院长;其主要社会兼职有:全国高等医药院校规划教材编委,中国天然药物杂志编委,天津市微生物学会理事。
人物经历
1990年毕业于沈阳药科大学,1993年赴日本留学,1998年获药学博士学位。 2000年作为南开大学引进人才回国在生命科学学院任教。2000年任微生物学系主任,2004年任生命科学学院副院长。主要社会兼职有:全国高等医药院校规划教材编委,中国天然药物杂志编委,天津市微生物学会理事。
研究方向
长期从事药学及免疫学相关研究,在生物技术制药,中药现代化等领域积累了丰富的经验。
主要贡献
曾先后主持和承担“863”项目“a-糖酶抑制性降糖中药复方的研究与开发”和“基于结构基因(蛋白)组的药物分子设计”;国家“十五”重点攻关“林业重大病虫害预警及控制技术研究”;国家自然科学基金“假单胞菌感染TS-1138转化ATC合成L-半胱氨酸代谢途径的研究”;天津市重点攻关“基因工程α-2b干扰素新型纯化工艺及制剂研究”;天津市重点基金“中药超灵敏感度免疫学分析法的研究”、“治疗哮喘天然药物的开发及分子机理研究”和“L-半胱氨酸高转化率菌株的构建及代谢调控理论研究”等多项科研项目,发表相关国内外学术论文70余篇, 其中SCI收录论文22篇,此外还申请发明专利多项。
1. Yuanyuan Hou, Xuelin Cao, Linyi 越南盾, Liqiang Wang, Binfeng Cheng, Qian Shi, Xiaodong Luo,* Gang Bai*. Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/时间 of flight 质量 spectrometry for β2AR agonist identification in alkaloidal extract of 鸡骨常山属 scholarIS系列坦克 Journal of Chromatography A.2012; 1227:203-9;
2. Lin-Yi DONG, Yun-hui ZHANG, Xuelin CAO1, Bin-Feng CHENG, Yuan-Yuan HOU, Jing WANG, Gang BA*, Guo-An LUO*. Rapid and Global Identification of Potentially Bioactive Crude Extracts from Chinese Medicinal Formula Chuanbeipipa Dropping Pills. Lat. Am. J. Pharm.2012; 31 (1): 18-26;
3. Liqiang Wang, Jiamin Peng, Binfeng Cheng, Jie Gao, Min Jiang, Gang Bai, Yuanyuan Hou*. 羧甲基纤维素 sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in 家鼠属 Pharmazie, 2012; 67(2):168-73;
4. J. Du, J. J. Duan, Q. Zhang, J. Hou, F. Bai, N. Chen, and G. Bai. Enzymatic Synthesis of L_色氨酸 from D,L-2-amino-Δ2-thiazoline-4-carboxylic Acid and Indole by 假单胞菌属 sp. TS1138 L-2-amino-Δ2-thiazoline-4-carboxylic Acid Hydrolase, S-carbamyl-L-cysteine Amidohydrolase and 埃希氏菌属 coli L-Tryptophanase. Applied Biochemistry and Microbiology, 2012; 48(2), 159-166;
5. Limei Ren, Xiaohong Qin, Xiaofang Cao, LeleWang, Fang Bai, Gang Bai*, Yuequan Shen*; Structural insight into substrate specificity of human intestinal maltase-glucoamylase. Protein \u0026 Cell, 2011; 2(10):827-36;
6. Xiaohong Qin, Limei Ren, Xue Yang, Fang Bai, Gang Bai*, Yuanquan Shen*; Structures of human pancreatic alpha- amylase in complex with acarviostatins: Implications for drug 设计 against Type II 糖尿病 Journal of Structural Biology, 2011;174(1):196-202;
7. Limei Ren, Xiaofang Cao, Peng Gen.G, Fang Bai*, Gang Bai; Study of the inhibition of two human maltase- glucoamylases catalytic domains by different α-glucosidase inhibitors. Carbohydr Res. 2011; 346(17), 2688-92;
8. Meng Peng, Guo Yuanqiang, Zhang Qi, Hou Jie, Bai Fang,* Gen.G Peng, Bai Gang. A novel amino-oligosaccharide isolated from the culture of Streptomyces strain PW638 is a potent inhibitor of α-amylase. Carbohydr Res. 2011; 346 (13):1898-902;
9. Hao Huang, Lanxin Ji, Shengyou Song, Jing Wang, Na Wei, Min Jiang, Gang Bai*, Guoan Luo*; Identification of the major constituents in Xuebijing Injection by HPLC-ESI-多发性硬化症 Phytochemical Analysis 2011;22(4):330-8;
10. Qian Shi, Yuanyuan Hou, Yang Yang, Gang Bai*; Protective effect of 甘草酸 against beta2-adrenergic receptor agonist-induced receptor internalization and cell apoptosis. Biol. Pharm. Bull. 2011;34(5):609-17;
11. Jie Hou, Qi Zhang, Xia Li, Yu Tang, Fang Bai, Qian Shi, Mei-rong Cao, Cui-hong Yang, De-ling Kong, Gang Bai*, Synthesis of novel folate conjugated fluorescent nanoparticles for tumor imaging. J Biomed Mater Res A. 2011;99(4):684-9;
12. Bai F, Xu H, Zhang Q, Qi X, Mou R, Bai G*, Qiao M*. Functional characterization of pfm in protein secretion and lung infection of 假单胞菌属 aeruginosa. Can J Microbiol. 2011; 57(10):829-37;
13. Tang Yu, Zhang Qi, Wang Long, pan PengWei, Bai Gang*; Preparation of 纤维素 magnetic microspheres with "the smallest critical size" and their application for microbial immunocapture. Langmuir 2010, 26(13): 11266-71;
14. Yang Yang, Shi Qian, Liu Ze, Li RuoJie, pan PengWei, Hou YuanYuan, Lu WanGe, Bai Gang*; The synergistic anti-asthmatic effects of glycyrrhizin and 沙丁胺醇 Acta Pharmacologica Sinica2010; 31(4):443-449;
15. Jing Wang, Na Wei, Hongzhi Zhao, Hao Huang, Min Jiang, Gang Bai*, Guoan Luo; Global Chemome Study by LC Coupled with DAD and ESI–Q–法洛四联症 MS of a Composite Traditional Chinese Medicine Qishenyiqi Dropping Pills. Chromatographia2010, 72, 431–440;
16. Gao Zhihui, Tang Yu, Chen Jiaqi, Bai Ru, Zhang Qi, Hou Yuanyuan, Lu Yaxin, Bai Gang*: A novel DPP-IV-resistant analog of 胰高血糖素like peptide-1 (GLP-1): KGLP-1 alone or in combination with long-acting PLGA microspheres. Peptides.2009; 30 (10):1874-1881;
17. Gao Zhihui, Zhang Qi, Cao Yu, pan Pengwei, Bai Fang, Bai Gang: Preparation of novel magnetic 纤维素 microspheres via cellulose binding domain-streptavidin linkage and use for mRNA isolation from eukaryotic cells and tissues. Journal of Chromatography A.2009; 216 (45): 7670-7676;
18. Zong Wei, Yang Yang, Peilin Zhang, Rosemary Andrianakos, Kouichi Hasegawa, Jungmook Lyu, Xi Chen, Gang Bai, Chunming Liu, Martin Pera, Wange Lu. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells. 2009; 27(12):2969-2978;
19. Wang Bin, Wang Shuai, Zhang Zhenxing, Yang 松属, Tian Ye, Wang Peng, Zhang Qi, Bai Gang. Alkynyl-modified Naphthalimide: Synthesis, crystal structure and fluorescence spectrum source. Chinese Journal of Structural Chemistry. 2009; 28(8): 1008-1012;
20. Geng Peng, Gang Bai*, Xiansheng Meng, Fang Bai, Guoan Luo: Screening for metabolites of acarviostatin family aminooligosaccharides in 家鼠属 using ultraperformance liquid chromatography coupled with electrospray ionization tandem 质量 spectrometry. Journal of Pharmaceutical and Biomedical Analysis2009; 50 (5) 917–923;
21. Qian Shi, Ze liu, Yang Yang, Peng Geng, Yuanyuan Zhu, Qi zhang, Bai Gang* : Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects. Acta Pharmacologica Sinica2009; 30(5):567-575;
22. Zhihui Gao, Gang Bai,* Jiaqi Chen, Qi Zhang, Pengwei pan, Peng Gen.G and Fang Bai: Development, Characterization, and Evaluation of a Fusion Protein of a Novel 胰高血糖素like Peptide-1 (GLP-1) Analogue and Human Serum Albumin inPichia pastoris.Biosci. Biotechnol. Biochem.2009;73(3):688-694;
23. Lihua Huai, Ning Chen, Wenbo Yang, Gang Bai: Metabolic Control Analysis of L-Cysteine Producing Strain TS1138 ofPseudomonas sp. Biochemistry (Moscow).2009;74(3):355-361;
24. Geng Peng, Gang Bai*, Shi Qian, Zhang Lei, Gao Zhihui, Zhang Qi: Taxonomy of the 链霉菌属 strain ZG0656 that produces acarviostatin alpha-amylase inhibitors and analysis of their effects on blood glucose levels in mammalian systems. Journal of Applied Microbiology2009;106 (2) 525–533
25. Peng Gen.G, Xiansheng Meng, Gang Bai,* Guoan Luo: Luo, Guoan: Profiling of acarviostatin family secondary metabolites secreted byStreptomyces coelicoflavus ZG0656 using ultraperformance liquid chromatography coupled with electrospray ionization 质量 spectrometry (UPLC/ESI-MS). Analytical Chemistry2008;80(19):7554-61;
26. GangBai,* Yang Yang, Qian Shi, Ze Liu, Qi Zhang, Yuan-yuan Zhu: Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist.Acta Pharmacologica Sinica. 2008;29(10):1187-1194;
27. Qi Zhang, Gang Bai,* Jiaqi Chen, Wang Tian, Yu Cao, Pengwei Pan, Chao Wang: Identification of antiviral mimetic peptides with interferon α-2b like activity from a random peptide library using a novel functional bio-panning method. Acta Pharmacologica Sinica. 2008; 29(5):634-640 ;
28. Peng Gen.G, Feng Qiu, Yuanyuan Zhu, Gang Bai*: Four acarviosine-containing oligosaccharides isolated from the culture of链霉菌属 coelicoflavus ZG0656 as potent α-amylase inhibitors. Carbohydrate Research. 2008; (343): 882–892;
29. Geng Peng, Gang Bai*: Two novel aminooligosaccharides isolated from the culture of Streptomyces coelicoflavus ZG0656 as potent α-amylase inhibitors. Carbohydrate Research. 2008; (343): 470-476;
30. Jiaqi Chen, Gang Bai,* Yu Cao, Zhihui Gao, Yuanyuan Zhu, Wenbo Yang : One-step purification of a fusion protein of glucagon-like peptide-1 and human serum albumin expressed in 毕赤酵母属 pastoris by an immunomagnetic separation technique..Biosci. Biotechnol. Biochem.2007;71 (11), 2655–2662;
31. Yu Cao, Wang Tian, Shenyan Gao, Wenbo Yang, Gang Bai*: Immobilization Staphylococcal_Protein A on magnetic cellulose microspheres for IgG affinity purification. Artificial Cells Blood Substitutes and Immobilization Biotechnology.2007;35(5):467-480;
32. Peng Gen.G, Yang Yang, Zhihui Gao, Yangsheng Yu, Qian Shi, Gang Bai*: Combined effect of total alkaloids from Feculae bombycis and natural flavonoids on 糖尿病 Journal of Pharmacy and Pharmacology. 2007;59(8): 1145-50;
33. Qi Zhang, Gang Bai,* Jiaqi Chen, Yangsheng Yu , Wang Tian, Wen-bo Yang: Use of an Enhanced Green Fluorescence Protein linked to a Single Chain Fragment Variable Antibody to LocalizeBursaphelenchus xylophilus Cellulase. Biosci. Biotechnol. Biochem.2007;71 (6), 1514-1520;
34. Yangsheng Yu, Gang Bai,* Chunqin Liu, Yu Cao, Peng Geng, Wenbo Yang: One-step elimination of L-cysteine desulfhydrase from crude enzyme extracts ofPseudomonas sp. TS1138 using an immunomagnetic affinity matrix improves the enzymatic production of L-cysteine. Journal of Chromatography B. 2007; 853 (6) :247–253 ;
35. Yu Cao, Qi Zhang, Chao Wang, Yuanyuan Zhu, Gang Bai*: Preparation of novel immunomagnetic cellulose microspheres via CBD-protein A linkage and its use for the isolation of interferon alpha-2b. Journal of Chromatography A. 2007; 1149: 228–235;
36. Jiaqi Chen, Gang Bai,* Yang Yang, Peng Gen.G, Yu Cao, Yanyan Zhu:Identifying 胰高血糖素like peptide-1 mimetics using a novel functional reporter gene high-throughput screen assay. Peptides. 2007 28(4):928-34;
参考资料

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目录
概述
人物经历
研究方向
主要贡献
参考资料