沈玉先，女，1965年生于
颍上县，1989年毕业于
安徽医科大学医学系，现为安徽医科大学教授，硕士生导师。沈玉先的主要社会任职有：中国药理学会抗炎免疫专业委员会委员、中国医刊编委、中国药理学通报编辑、Free Radical Bio Med, Neurosci Res,J Pharm Pharmacol,
Arch Linux Med Res, Acta Pharmacol Sin, Medical Science Monitor等期刊的审稿人。发表专业论文80余篇，其中2002年度以第一作者发表SCI论文数在全国科技论文统计中居医药类首位（4篇）。目前承担的课题有国家自然科学基金面上项目、教育部人才基金、教育部重点项目、中国博士后基金一等资助、教育部回国人员基金、安徽省优秀人才基金等，并作为主要研究人员参与国家973项目的研究。参编大型参考书4部如《药理实验方法学》、《中华临床药物学》（编委）、《治疗学的药理学基础》等。
人物经历
1984 ~ 1989
安徽医科大学医学系 本科/学士。
1989 ~ 1992 安徽医科大学
药理学专业 研究生/硕士。
1997 ~ 2000 安徽医科大学药理学专业 研究生/博士。
1992 ~ 1995 安徽医科大学临床药理研究所 助教。
1995 ~ 1999 安徽医科大学临床药理研究所 讲师。
1999 ~ 2003 安徽医科大学临床药理研究所 副教授。
2003 ~ 2004 美国马利兰大学生物技术研究所 博士后研究。
2005 ~ 2008
中国科学技术大学生命科学院 博士后研究。
2003 ~ 2007
安徽医科大学临床
药理学研究所 教授。
2007 ~ 2010 安徽医科大学“重要遗传疾病基因资源利用”教育部重点实验室 教授。
2009 ~ 2010
安徽医科大学护理学院 副院长。
2010 ~ 2012
安徽医科大学基础医学院 教授，副院长。
2012 ~ 安徽医科大学基础医学院 教授，院长。
科研项目
主持的科研项目有：
1. 国家自然科学基金委员会，面上项目，81973336，神经因子MANF介导的单核/巨噬细胞表型及功能的可塑性对肝纤维化的抑制作用及机制研究，2020-01至2023-12，在研，主持；
2. 国家自然科学基金委员会，面上项目，81673438，肝细胞源性神经营养因子MANF经外泌体靶向HSCs的抗肝纤维化作用及机制研究，2017-01至2020-12，在研，主持；
3. 安徽省转化医学研究院，科研基金项目，2017zhyx34，基于新型神经营养因子MANF的双级靶向纳米递送系统的设计及其在
脑梗死治疗中的应用，2018-01至2020-12，在研，主持；
4.
安徽省教育厅，安徽省领军人才团队项目，慢性应激与重大疾病研究，2017-01至2018-12，400万元，已结题，团队带头人；
5. 国家科技部，国家重点研发计划重大慢性非传染性疾病防控研究项目，2016YFC1305902，基于单细胞基因表达谱的神经环路解析，2016-09至2020-12，在研，子课题负责人；
6. 国家自然科学基金委员会，面上项目，81372576，新型神经营养因子MANF对肝细胞癌的抑制作用及其机制研究，2014-01至2017-12，已结题，主持；
7. 国家自然科学基金委员会，重大研究计划（培育项目），91129729，
内质网应激在
乙型肝炎肝硬化肝癌转化过程中的调节机制及相关药物作用靶分子筛选，2012-01至2014-12，已结题，主持；
8. 国家自然科学基金委员会，面上项目，81173074，炎症诱导的ARMET
转录激活及其对NF-κB信号通路的调节机制，2012-01至2015-12，已结题，主持；
9. 国家教育部，博士点基金（博导类），20113420110004，炎症诱导的ARMET转录激活及其对NF-κB信号通路的调节机制，2012-01至2014-12，已结题，主持；
10. 国家自然科学基金委员会，面上项目，81072651，
内质网应激蛋白ARMET对
关节炎滑膜
细胞过度增殖的负性调控，2011-01至2011-12，已结题，主持；
11. 国家自然科学基金委员会，面上项目，30772557，泛素连接酶Hrd1介导的tau蛋白降解，2008-01至2010-12，已结题，主持；
12. 安徽省科技厅，科技攻关计划项目，07010300191，内质网应激蛋白stresslin检测方法的建立及临床应用， 2007-01至2009-12，已结题，主持；
13. 国家自然科学基金委员会，面上项目，30572219，泛素连接酶hHrd1对1-
抗胰蛋白酶Z变异型的降解的调控机制，2006-01至2008-12，已结题，主持；
14. 国家教育部，重点项目，206067，泛素连接酶 hHrd1和异常磷酸化tau功能性相互作用研究， 2006-1至2008-12 ，已结题，主持；
15. 国家教育部，新世纪优秀人才支持计划，NCET-04-0589，泛素-蛋白酶体通路调控1-抗胰蛋白酶Z变异型的降解，2005-01至2007-12，已结题，主持；
16.
中国博士后科学基金会，一等资助，2005038011，泛素连接酶 hHrd1和异常磷酸化tau功能性相互作用研究，2005-01至2007-12，已结题，主持。
主要论文
1. Hou C, Wang D, Zhao MX, Ballar P, Zhang XR, Mei Q, Wang W, Li X, Sheng Q, Liu J, Wei CS, Shen YJ, Yang Y, Wang P,
邵姓 JT, Sun Y*, Shen YX*. MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis. Acta Pharmaceutica Sinica B. Jun-13, 2023. Accepted (IF=14.5).
2. Yang L, Shen WW, Shao W, Zhao Q,
pang GZ, Yang Y, Tao XF, Zhang WP, Mei Q, Shen YX*. MANF ameliorates DSS-induced mouse
结肠炎 via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway. Acta Pharmacol Sin. 2023 Jun; 44(6): 1175–1190 (IF=8.2).
3. Shen WW, Yang L, Yang Y, Wang P, Tao XF, Shen YJ, Wang S, Shen YX*. PRDX6 promotes fatty acid oxidation via PLA2-dependent PPARα activation in rats fed high-fat diet. Antioxid Redox Signal. 2023 Feb 7 (IF=6.6).
4. Chen H, Zhu T, Huang X, Xu WS, Di Z, Ma YY, Xue M, Bi SX, Shen YJ, Yu YY, Shen YX*, Feng LJ*. Xanthatin suppresses proliferation and tumorigenicity of glioma
细胞s through autophagy inhibition via activation of the
pi3kAkt-mTOR pathway. Pharmacol Res Perspect. 2023 Feb; 11 (1): e1041.
5. Tao XF, Wang D, Liang YY, Yang L, He EG, Zhou J, He YF, Liang JX, Wang P, Chhetri G, Li Q, Shen YJ, Shen YX*. PRDX6 inhibits hepatic stellate cells acti-vation and fibrosis via promoting MANF secretion.
生物医学 \u0026 Pharma-cotherapy 2022, 156,113931.（IF=7.5）
6. Shen QY, Wang D, Xu HY, Wei CS, Xiao XY, Liu J, Shen YJ, Fang L, Feng LJ, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor attenuates acute lung injury via inhibiting macrophages' activation. Biomed Pharma-cother 2022, 150: 112943.（IF=7.5）
7. Xie YJ, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zim-mermann MT, Wilcox DA, Gutterman DD, Shen YX*, Zhang DX*. NADPH oxidase 4 contributes to TRPV4‑mediated endothelium‑dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. Basic Res Cardiol 2022, 117(1): 24. (IF=9.5)
8. Hou X#, Liu Q#, Gao YM#, Yong L, Xie HY, Li WT, Zhou YP, Liu J, Feng LJ, Xu L, Shen YX*, Wang H*. Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate
对乙酰氨基酚induced acute liver injury via p38 MAPK pathway. Cell
死亡 Dis 2022, 13(2): 100.（IF=9.0）
9. Xu HY, Jiao YH, Li SY, Zhu X, Wang S, Zhang YY, Wei YJ, Shen YJ, Wang W, Shen YX*, Shao JT*. Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in
鼠科 via enhancing ASS1 activity and activating AMPK pathway. Acta Pharmacol Sin. 2022, 44(1):157-168.（IF=8.2）
10. Zhao TT#,
越南盾 FQ#, Hu XL, Xu YL, Wei WM, Liu R, Yu F, Fang WJ*, Shen YX*, Zhang ZP*. Dynamic Tracking of p21 mRNA in Living
细胞s by Sticky-Flares for Visual Evaluation of Tumor Treatment Effect. Nanoscale 2022; 14 (5): 1733-1741.（IF=6.7）
11. Liu C, Liu J, Shao JT, Huang C, Dai XL, Shen YJ, Hou WS, Shen YX*, Yu YQ*. MAGED4B Promotes Glioma Progression via Inactivation of the TNF α induced Apoptotic Pathway by Down regulating TRIM27 Expression. Neurosci Bull 2022, 39(2):273-291 (IF=5.6).
12. Zhao Q, Sheng MF, Wang YY, Wang XY, Liu WY, Zhang YY, Ke TY, Chen S, Pang GZ, Yong L, Ding Z, Shen YJ, Shen YX*, Shao W*. LncRNA Gm26917 reguates inflammatory response in macrophages by enhancing Annexin A1 ubiquitination in LPS-induced acute liver injury. Frontiers in
药理学 2022, 13:975250 (IF=5.6).
13. Li H, Wu ZS, Zhong RL, Zhang QK, Chen QX, Shen YX*. PRDX6 knockout restrains the malignant progression of intrahepatic
胆管癌Med Oncol. 2022 Oct 8;39(12):250.（IF=3.738）
14. Ren CP#, Gao Y#, Zhang C#, Zhou C, Hong Y, Qu MS, Zhao ZR, Du YN, Yang L, Liu BY, Wang SY, Han MF*, Shen YX*, Liu Y*. Respiratory Mucosal Im-munity: Kinetics of Secretory Immunoglobulin A in Sputum and Throat Swabs From COVID-19 Patients and Vaccine Recipients. Front Microbiol 2022, 13: 782421.（IF=6.064）
15. Song MM*, Chen J, Ye SM, Lu DP, Zhang GY, Liu R, Shen YX*. Targeted de-livery of edaravone by liposomes for the treatment of ischemic stroke. Nano
药品 2022,https://doi.org/102217/nnm-2021-0490.（IF=5.5）
16. Wang P, Yang Y, Pang GZ, Zhang CY, Wei CS, Tao XF, Liu J, Xu JM, Zhang WP*, Shen YX*. Hepatocyte-derived MANF is protective for
利福平induced cholestatic hepatic injury via inhibiting ATF4-CHOP signal activation. Free Radic Biol Med 2021, 162:283-297 (IF=6.17).
17. Yang Y, Wang P, Zhang CY, Huang F, Pang GZ, Wei CS, Lv CM, Chhetri G, Jiang TC, Liu J, Shen YJ, Shen YX*. Hepatocyte-derived MANF alleviates he-patic ischemia-reperfusion injury via regulating endoplasmic reticulum
应力- in-duced apoptosis in
鼠科 Liver Int 2021, 41 (3): 623-639 (IF=5.175).
18. Hou C#, Mei Q#, Song XG, Bao Q, Li X, Wang D, Shen YX*. Mono-macrophage-Derived MANF Protects Against
脂多糖Induced Acute
肾脏 Injury via Inhibiting Inflammation and Renal M1 Macrophages. Inflammation 2021, 44 (2): 693-703 (IF=5.1).
19. Liu J#, Wu ZS#, Han D, Wei CS, Liang YY, Jiang TC, Chen L, Sha MQ, Cao YJ, Huang F,
Gen.G XP, Yu JS, Shen YJ, Wang H, Feng LJ, Wang D, Fang SY, Wang SY*, Shen YX*. MANF inhibits liver cancer via SUMOylation-related suppres-sion of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition. Hepatology 2020, 71(4):1262-1278 (IF=17.425).
20. Chhetri G, Liang YY, Shao JT, Han D, Yang Y, Hou C, Wang P, Tao XF, Shen YJ, Jiang TC, Feng LJ, Shen YX*. Role of Mesencephalic Astrocyte-Derived Neu-rotrophic Factor in
乙醇Induced Liver Injury. Oxid Med Cell Longev 2020, 2020: 9034864 (IF=5.076).
21. Ma YY, Di ZM, Cao Q, Xu WS, Bi SX, Yu JS, Shen YJ, Yu YQ, Shen YX*, Feng LJ*. Xanthatin induces glioma cell apoptosis and inhibits tumor growth via acti-vating endoplasmic reticulum
应力-dependent CHOP pathway. Acta Pharmacol Sin 2020, 41: 404-414 (IF=4.01).
22. Zhang N#, Shen YJ#, Pang GZ, Chu SY, Han W, Mei Q, Hu XL,
越南盾 FQ, Shen YX*, Zhao TT*. Ratiometric fluorescent nano-sensor for dosage-sensitive visu-al discrimination of glucose based on electron transfer mechanism. Microchem J 2020, 158: 105188 (IF=5.304).
23. Shao JT*, Zaro J, Shen YX*. Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intra
细胞ular Fate. Int J Nanomedi-cine 2020, 15:9355–9371 (IF=6.4).
24. Xu RY, Pang GZ, Zhao Q, Yang L, Chen S, Jiang L, Shen YX*, Shao W*. The momentous role of N6‐methyladenosine in lung cancer. J Cell Physiol 2020, 236(5): 3244-3256 (IF=6.513).
25. Fei MY#, Song MM#, Wang P, Pang GZ, Chen J, Lu DP, Liu R, Zhang GY, Zhao TT, Shen YX*, Yu YQ*. Folic acid modified
四氧化三铁 nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging. RSC Adv 2020, 10(9), 5294-5303 (IF=3.361).
26. Xu SC, Di ZM, He YF, Wang RJ, Ma YY, Sun R, Li J, Wang T, Shen YJ, Fang SY, Feng LJ*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ
毒性 via attenuating Aβ-induced endoplasmic re-ticulum stress, J Neuroinflammation 2019, 16(1):35.
27. Hou C#,Wang D#, Li X, He YF, Wei CS, Jiang R, Liu J , Feng LJ, Shen YX*. MANF regulates splenic macrophage differentiation in
鼠科 Immunol Lett 2019, 212: 37-45.
28. Shi TL, Zhang L,
成姓 QY, Yu JS, Liu J, Shen YJ, Feng XJ, Shen YX*. Xan-thatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells. Eur J Pharmacol 2019, 843: 1–11.
29. Feng LJ#, Murugan M#, Bosco DB, Liu Y, Peng JY, Worrell GA, Wang HL, Ta LE, Richardson JR, Shen YX*, Wu LJ*. Microglial Proliferation and Monocyte Infiltration Contribute to Microgliosis following Status Epilepticus, Glia 2019, 67(8): 1434-1448.
30. Xiang HH#, Song MM#, Fei MY, Wang RJ, Tao XF, Shen YX*, Yu YQ*. Facile synthesis of multifunctional nanocomposites with good compatibility for efcient dual mode T1 and T2 magnetic
共振 imaging and gene delivery. Appl Na-nosci 2019, 9(8): 2019-2030.
31. He KW, Li JJ, Shen YX*, Yu YQ*. pH-Responsive
聚电解质 coated
钆 氧化物doped mesoporous silica nanoparticles (GdO@MSNs) for synergis-tic drug delivery and magnetic
共振 imaging enhancement, J Mater Chem B 2019, 7(43):
小行星68406854.
32. Bi SX, Li XH, Wei CS, Xiang HH, Shen YX*, Yu YQ*. The antitumour growth and antiangiogenesis effects of xanthatin in murine glioma dynamically evaluated by dynamic contrast‐enhanced magnetic
共振 imaging. Phytother Res 2019, 33(1): 149-158.
33. Wu J, Wang H, Li Q, Guo QY, Tao SQ, Shen YX*, Wu ZS*. The oncogenic im-pact of RNF2 on cell proliferation, invasion and migration through EMT on mammary carcinoma. Pathol Res Pract. 2019; 215 (9): 152523.
34. Wang D, Hou C, Cao YJ,
成姓 QY, Zhang L, Li H, Feng LJ, Shen YX*. XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF
助催化剂 region in hepatitis B. Int J Bio-chem Cell Biol 2018, 99: 140-146.
35. Song MM, Xiang HH, Fei MY, Lu DP, Jiang TC, Yu YQ, Liu R*, Shen YX*. Facile fabrication of
H₂Odispersible nanocomposites based on hexa-peri-hexabenzocoronene and
四氧化三铁 for dual mode imaging (fluorescent/MR) and drug delivery. RSC Adv 2018, 8(71): 40554-40563.
36. Wang CH, Jiang TC, Qiang WM, Zhang L, Feng LJ, Shen YJ, Shen YX*. Acti-vator protein 1 is a novel regulator of mesencephalic astrocyte derived neu-rotrophic factor tranion. Molecular Medicine Reports 2018, 18(5): 5765-5774.
37. Feng LJ, Zhang J, Zhu N, Ding Q, Zhang XJ, Yu JS, Qiang WM, Zhang ZT, Ma YY, Huang DK, Shen YJ, Fang SY, Yu YF, Wang HP, Shen YX*. Ubiqui-tin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z vari- ant/alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy 2017, 13(4):
686702.
38. Zhang WP, Chen LH, Feng H, Wang W, Cai Y, Qi F, Tao XF, Liu J, Shen YJ, Ren XF, Chen X, Xu JM*, Shen YX*.
利福平induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and en-hancing the Nrf2-mediated adaptive response. Free Radic Biol Med 2017,112: 24-35.
39. Zhang D, Li MM,
越南盾 Y, Zhang XH, Liu XY, Chen ZM, Zhu YJ, Wang HM, Liu XW, Zhu JL, Shen YJ, Korner H, Ying SC*, Fang SY* and Shen YX*. 1α, 25-Dihydroxyvitamin D3 up-regulates IL-34 expression in
shSY5Y neural cells. Innate Immun 2017, 23(7): 584-591.
40. Song MM*, Xu HL, Liang JX, Xiang HH, Liu R, Shen YX*. Lactoferrin modi-fied graphene
氧化物 iron oxide nanocomposite for glioma-targeted drug delivery. Mater Sci Eng C Mater Biol Appl 2017, 77: 904-911.
41. Liu J, Tao XF, Zhang J, Wang P, Sha MQ, Ma Y, Geng XP, Feng LJ, Shen YJ, Yu YF, Wang SY, Fang SY, Shen YX*. Small ubiquitin-related modifier 1 is in-volved in hepatocellular carcinoma progression via mediating p65 nuclear translo-cation. Oncotarget 2016, 7(16): 22206-22218.
42. Wang XY, Song MM, Bi SX, Shen YJ, Shen YX*, Yu YQ*. MRI Dynamically Evaluates the Therapeutic Effect of Recombinant Human MANF on Ischemia/ReperfusionInjury in
家鼠属 Int J
摩尔 Sci 2016, 17(9): 1476.
43. Fang WJ, Han C, Zhang HB, Wei WM, Liu R, Shen YX*. Preparation of
氨基functionalized magnetic nanoparticles for enhancement of bacterial capture ef-ficiency. RSC Adv 2016, 6(72): 67875-67882.
44. Chen LJ, Feng LJ, Wang X, Du J, Chen Y, Yang W, Zhou CY,
成姓 L, Shen YJ, Fang SY, Li J*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway. Sci Rep 2015, 5: 8133.
45. Liu J, Sha MQ, Wang QF, Ma Y, Geng XP, Gao YF, Feng LJ, Shen YJ, Shen YX*. Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma. BMC Cancer 2015, 15: 675.
46. Liu J, Zhou CY, Tao XF, Feng LJ, Wang X, Chen LJ, Li CJ, Huang DK, Fang SY, Shen YX*. ER
应力inducible protein MANF selectively expresses in human spleen. Hum Immunol 2015, 76(11): 823-830.
47. Chen LJ, Wan LJ, Du J*, Shen YX*. Identification of MANF as a protein inter-acting with RTN1-C. Acta Biochim Biophys Sin (Shanghai) 2015, 47(2): 91-97.
48. Yang W, Shen YJ, Chen Y, Chen L, Wang L, Wang HP, Xu SC, Fang SY, Fu Y, Yu YQ*, Shen YX*. Mesencephalic astrocyte-derived neurotrophic factor pre-vents neuron loss via inhibiting ischemia-induced apoptosis. J Neurol Sci 2014, 344 (1-2): 129-138.
49. Wang LK, Tang WX, Jiang TC, Lu P, Li YH, Sun AM, Shen YJ, Chen Y, Wang HP, Zong ZJ, Wang YQ, Chen LJ, Shen YX*. Endoplasmic Reticulum
应力 is involved in the Neuroprotective Effect of Propofol. Neurochem Res 2014; 39(9):1741-1752.
50. Wang JJ, Chen QY, Wang X, Zu BB, Xu JH, Xu YH,
左姓 XB, Shen YJ, Wang J, Shen YX*. Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus. Am J Med Sci 2014, 348(6): 465-473.
51. Chen ZM, Zhu MY, Pan X, Zhu YJ, Yan H, Jiang TC, Shen YJ,
越南盾 XW, Zheng N, Lu JS, Ying SC*, Shen YX*. Inhibition of
肝炎 B
病毒 replication by SAMHD1. Biochem Biophys Res Commun 2014, 450(4): 1462-1468.
52. Feng LJ, Jiang TC, Zhou CY, Yu CL, Shen YJ, Li J*, Shen YX*. Activated mac-rophage-[like] synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in
抗原induced
关节炎 Inflamm Res 2014; 63(5): 335-346.
53. Wang L, Chen L, Wang QF, Wang LJ, Wang HB, Shen YJ, Li XH, Fu Y, Shen YX*, Yu YQ*. Circulating endothelial progenitor cells are involved in VEGFR-2-related endothelial differentiation in glioma. Oncol Rep 2014, 32(5): 2007-2014.
54. Chen ZL, Zhong YW, Wang Y, Xu S, Liu Z, Baskakov IV, Monteiro MJ, Kar-bowski M*, Shen YX*, Fang SY*. Ubiquitination-Induced
荧光 Com-plementation (UiFC) for Detection of K48 Ubiquitin Chains In Vitro and in Live Cells. PLoS One 2013, 8(9): e73482.
55. Shen YJ#, Sun AM#, Wang YH, Cha DQ, Wang HP, Wang FC, Feng LJ, Fang SY*, Shen YX*. Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation 2012, 9: 254.
56. Shen YX*, Sun AM, Fang S, Feng LJ, Li Q, Hou HL, Liu C, Wang HP, Shen JL, Luo J, Zhou JN*. Hrd1 Facilitates Tau Degradation and Promotes Neuron Sur-vival. Curr
摩尔 Med 2012, 12(2): 138-152.
57. Wang HP, Li Q, Shen YJ, Sun AM, Zhu XG, Fang SY, Shen YX*. The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and in-creases its
溶解度 摩尔 Cell Biochem 2011, 346(1-2): 137-145.
58. Yu YQ, Liu LC, Wang FC, Liang Y, Cha DQ, Zhang JJ, Shen YJ, Wang HP, Fang S, Shen YX*. Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. J Cereb Blood Flow Metab 2010, 30(1): 79-91.
59. Feng LJ, Shen YX*, Sun AM, Shen YJ, Fang SY, Li J*. Endoplasmic reticulum stress is involved in okadaic acid-induced tau phosphorylation and neurotoxic ef-fects of okadaic acid. Neural Regen Res 2010, 5(20): 1534-1540.
60. Yue L, Shen YX*, Feng LJ, Liu LH, Chen FH, Wu Q, Wang Hua. Blockage of the formation of new blood vessels by recombinant human endostatin contributes to the regression of rat adjuvant
关节炎 Eur J Pharmacol 2007, 567(1-2): 166-170.
61. Shen YX, Ballar P, Apostolou A, Doong H, Fang SY. ER stress differentially reg-ulates the stabilities of ERAD ubiquitin ligases and their substrates. Biochem
闭姓ophys Res Commun 2007, 352(4): 919-924.
62. Shen YX*, Zhang GG, Liu LH, Wang H, Xu SY. Suppressive of effects of
墨尔本atonin on amyloid peptide-induced glial activation in rat hippocampus. Arch Med Res 2007, 38(3): 284-290.
63. Shen YX, Ballar P, Fang SY*. Ubiquitin ligase gp78 increases
溶解度 and fa-cilitates degradation of the Z variant of alpha-1-antitrypsin. Biochem Biophys Res Commun 2006, 349(4): 1285-1293.
64. Yue L, Wang H, Liu LH, Shen YX*, Wei W*. Anti-adjuvant
关节炎 of recom-binant human endostatin in rats via inhibition of angiogenesis and proinflamma-tory factors. Acta Pharmacol Sin 2004; 25(9): 1182-1185.
65. Shen YX*, Xu SY, Wei W, Sun XX, Liu LH, Yang J, Dong C. The protective ef-fects of melatonin from oxidative damage induced by amyloid beta-peptide 25-35 in middle-aged
家鼠属 J Pineal Res 2002, 32(2): 85-89.
66. Shen YX*, Xu SY, Wei W, Wang XL, Wang H, Sun X. Melatonin blocks rat hippocampal neuronal apoptosis induced by amyloid beta-peptide 25-35. J Pineal Res 2002, 32(3): 163-167.
67. Shen YX*, Xu SY, Wei W, Sun XX, Yang J, Liu LH, Dong C. Melatonin reduces memory changes and neural oxidation damage in mice treated with D-galactose. J Pineal Res 2002; 32(3): 173-178.
68. Shen YX*, Wei W, Xu SY. Protective effects of melatonin on the cortical -hippocampal neurotoxicity induced by amyloid beta-peptide 25-35. Acta Phar-macol Sin 2002, 23(1): 71-76.
69. Shen YX*, Wei W, Yang J, Liu C, Dong C, Xu SY. Improvement of melatonin to learning and memory impairment induced by amyloid -peptide 25~35 in elder
家鼠属 Acta Pharmacol Sin 2001, 22(9): 797-803.
参考资料：
社会职务
沈玉先任中国药理学会抗炎免疫专业委员会委员、
世界中医药学会联合会中医药免疫专业委员会常务理事、安徽省药理学会常务理事、安徽省色谱学会常务理事；沈玉先还任Journal of Pharmacological Science编委、中国药理学通报编委、安徽医科大学学报编委；沈玉先还是NatComm、FreeRadicalBioMed、BrainBehaviorandImmunity、SciRep等10余种SCI源期刊的审稿人。
参考资料：
主要成就
2000年获第四届中国
药理学学会Servier青年药理学工作者奖；
2003年入选安徽省拔尖人才；
2004年入选教育部“新世纪优秀人才支持计划”；
2005年获中国博士后基金一等资助；
2006年入选安徽省学术科技带头人；
2007年获安徽省人才开发基金资助；
2014年安徽省科学技术奖（科技进步类）
二等奖（第三完成人）；
2019年安徽省科学技术奖（自然科学类）
一等奖（第一完成人）；
2019 年第五届互联网+大学生创新创业大赛全国铜奖、安徽省金奖 (指导教师)；
2015年安徽省科学技术奖（科技进步类）二等奖（第二完成人）；
2022年9月，被安徽省委教育工委、省教育厅确定为2022年度“全省教书育人楷模”。
参考资料
沈玉先.安徽医科大学基础医学院.2024-09-16