张世华，男，博士，现任安徽农业大学理学院副教授。他的主要研究方向包括植物（茶树）逆境和品质成分相关的计算系统生物学、功能基因组学以及化学信息学等。张世华在华中科技大学物理学院生物物理学专业攻读硕士学位，主要从事非编码脱氧核糖核酸序列的算法设计和数学建模。后在哈尔滨医科大学生物信息学科学与技术学院生物信息学专业攻读博士学位，主要从事计算系统生物学（网络生物学）方向的研究。2011年9月，张世华加入安徽农业大学。迄今，他已在生命科学领域相关的期刊如《Briefings in Bioinformatics》《BMC plant biology》《Gene》和《FEBS letters》上发表多篇SCI论文。张世华还是SM Journal of Bioinformatics and Proteomics期刊的editor member，同时也是Nucleic Acids Research、Database、Scientific Reports等杂志的referee。

安徽农业大学理学院副教授2003年9月至2006年7月在华中科技大学物理学院生物物理学专业攻读硕士学位，主要从事非编码脱氧核糖核酸序列的算法设计和数学建模；2007年8月至2010年7月在哈尔滨医科大学生物信息学科学与技术学院生物信息学专业攻读博士学位，

为本科生、研究生系统讲授《生物信息学》、《生物统计学》、《食品实验设计与数据分析》等课程。

植物（茶树）逆境和品质成分相关的计算系统生物学、功能基因组学以及化学信息学等方向，近阶段尤其关注二代测序（新一代测序）多层面组学数据的整合分析

作为主要参与人，参加全国农林院校“十二五”规划教材《生物信息学》的编写，中国农业出版社。

1）基于网络建模解析水稻在不同非生物逆境下miRNA的串扰调控关系(国家自然科学青年基金，31301248)

2）植物非生物逆境下microRNA网络调控机制分析平台的构建(中国博士后科学基金面上项目，2013M531498）

3）2014年安徽农业大学生物统计学学科点学科骨干培育项目（2014XKPY-37)

4）基于文本挖掘的人类遗传疾病的相关性研究（11541298，黑龙江省教育厅科学技术研究项目）

firstauthor and corresponding papers:

1）Shihua Zhang*, Hongdong Xuan*, Liang Zhang, Sicong Fu, Yijun Wang, Hua Yang, Yuling Tai, Youhong Song, Jinsong Zhang, Chi-Tang Ho, Shaowen Li andXiaochun Wan, TBC2health: a database of experimentally validated health-beneficial effects of tea bioactive compounds,Briefings in 生物信息学 2016, doi: 10.1093/bib/bbw055

2) Linzhong Zhang, Hongdong Xuan, Yongchun Zuo, Gaojian XuPing Wang, Youhong Song,Shihua Zhang*,Topologicalcharacteristicsoftargetgenesregulatedbyabiotic-stress-responsiblemiRNAsinariceinteractomenetwork,Functional\u0026 Integrative Genomics 2016 DOI: 10.1007/S10142-016-0481-4 (通讯)

3) Hongdong Xuan, Linzhong Zhang, Xueshi Liu, Guomin Han, Juan Li, Xin Li, Aiguo Liu, Mingzhi Liao,Shihua Zhang*, PLNlncRbase: a resource for experimentally identified lncRNAs in plants,Gene2015, 573, 328-332 (通讯)

4) Leijie Li, Liangcai Zhang, Guiyou Liu, Rennan Feng, Lei Yang,Shihua Zhang*, Mingzhi Liao*, and Jinlian Hua*, Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks,PLoS ONE2014 9(8): e105180. doi:10.1371/journal.pone.0105180 (通讯)

5) Hongdong Xuan, Xin Li, Shenrong Ren,Shihua Zhang*, Modular organization of the human disease genes:a text-based network inference,Bioinformation2015,11(9): 432-436 (通讯)

6)Shihua Zhang, Yi Yue, Liang Sheng, Yunzhi Wu, Guohua Fan, Ao Li, Xiaoyi Hu, Mingzhu ShangGuan and Chaoling Wei*, PASmiR: a literature-curated database for miRNA molecular regulation in 植物界 response to abiotic stress,BMC plant biology2013, 13 (33), 1-8

7)Shihua Zhang, Jing Xu, Chaoling Wei*, Sequence periodic pattern of HERV LTRs: A matrix simulation algorithm,Journal of biosciences2012, 37(1), 1-6

8)Shihua Zhang, Chunyu Wang, Bo Xi, Xia Li*, Association between tumor necrosis factor-α-308G/A polymorphism and chronic obstructive pulmonary disease: An update,Respirology2011, 16, 107-115

9)Shihua Zhang, Chao Wu, Xia Li*, Xi Chen, Wei Jiang, Binsheng Gong, Jiang Li , Yuqing Yan, From phenotype to gene: detecting disease-specific gene functional modules via a text-based disease phenotype network construction,FEBS letters2010, 584, 3635-3643

10)Shihua Zhangand Yi Xiao*, Quasiperiodic property in Alu repeats,Physical Review E2006, 74, 022901-4

Co-authorpapers:

11）Yuan Yang, Wenjing Wang, Liangcai Zhang,Shihua Zhang, Guiyou Liu, Yingcui Yu, Mingzhi Liao, Association of single 核苷酸 polymorphism rs6983267 with the risk of prostate cancer, Oncotarget. 2016 Mar 18. doi: 10.18632/oncotarget.8186.

12) Yongchun Zuo, Wenxia Su,Shihua Zhang, Shanshan Wang, Chengyan Wu, Lei Yang, Guangpeng Li, Discrimination of membrane transporter protein types using K-nearest neighbor method derived from similarity distance of total diversity measure,Molecular BioSystems2015 11(3):950-7.

13）Wei Liu, Xuefeng Bai, Yuejuan Liu, Wei Wang, Junwei Han, Qiuyu Wang, Yanjun Xu, Chunlong Zhang,Shihua Zhang, Xuecang Li, Zhonggui Ren, Jian Zhang, Chunquan Li, Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case,Scientific Reports, 2015, 5:1-15

14）Liang Zhang, Yuhui Han, Jinjun Shan, Yuhong Liang, Liwei Xu,Shihua Zhang, JunSong Li, Xiaochun Wan, Simultaneous determination of seven catechins in rat plasma by ultra-high performance liquid chromatography tandem 质量 spectrometry and its application to a pharmacokinetics study,Analytical Methods2015, 7(22), 9415-9420

15）Chao Wu, Fan Zhang, Xia Li,Shihua Zhang, Jiang Li, Fei Su, Kongning Li, Yuqing Yan, Composite functional module inference: detecting cooperation between transcriptional regulation and protein interaction by mantel test,bmc Systems Biology2010, 4:82

Conference papers:

16)Shihua Zhang, Mingzhi Liao, Xia Li*, The modular property implied in the human disease gene network,The 5th International Conference on Frontier of Computer Science and Technology - Workshop on 生物信息学 and System Biology, Start Page 58, Wuhan, June 4-6, 2010

17)Shihua Zhang, Chao Wu, Xia Li*, Mingzhi Liao, Yuqing Yan, Sequence periodicity of human endogenous retroviruses,The 5th International Conference on Frontier of Computer Science and Technology - Workshop on 生物信息学 and System Biology, Start Page 47, Wuhan, June 4-6, 2010