⑴ The development of new compounds which inhibit the acute rejection using rat heart transplant model. (Active Biotech AB,Lund,Sweden2001-2004)经费150,000美元
⑵ Tutor for the international course of microsurgery,and scientific adviser (DiLab,Lund,Sweden 2003-2006)经费30,000美元
⑶ Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants. (Novo Nordisk,Denmark 2003-2006)经费60,000美元
Junjie Xia,1 Jibing Chen,2 Wei Shao,1 Tianshu Lan,1 Yongzhi Wang,1 Baiyi Xie,1 Henrik Thorlacius,3 Feng Tian,2 Ruxin Huang,4 Zhongquan Qi,Suppressing memory T cell activation induces islet allograft tolerance in allo
抗原primed mice. Transplant International. (*通讯作者)(accepted 2010)Feng Wang,JibingChen,WeiShao,Baiyi Xie,YongzhiWang,TianshuLan,HenrikThorlacius,Zhongquan Qi. Anti-CD44 Monoclonal Antibody Inhibits Heart Transplant Rejection Mediated by Allo
抗原primed CD4+Tm in Nude Mice. Transplant Immunology. (*通讯作者)(accepted 2010)Lan Tianshu,Chen Jibing,Kang Xiangpeng,Wang Feng,Wang Yongzhi,Xia Junjie,Qi Zhongquan. Pre-contact of tolerance circumstance protect the allograft from attacking by memory T cells. Scandinavian Journal of Immunology(*通讯作者)(accepted 2010)Xiangpeng Kang,Jibing Chen,Qing Qin,Feng Wang,Yongzhi Wang,Tianshu Lan,Shuo Xu,Feiyu Wang,Junjie Xia,Henrik Ekberg,Zhongquan Qi,Zhongchen Liu.Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in allo
抗原primed mice. Transpl Immunol. (*通讯作者)(accepted 2010)Baiyi Xie,Jibing Chen,Feng Wang,Tianshu Lan,Yongzhi Wang,Junjie Xia,Zhi Li,Qingxiang Xie,Ruxin Huang,Zhongquan Qi. Monoclonal Antibody Treatment to Prolong the Secondary Cardiac Allograft Survival in Allo
抗原primed
鼠科 Scandinavian Journal of Immunology. (*通讯作者)(accepted 2010)Liang H,Liao C,Qi Z,Sha C,Xie B,Chen J,Xia J,Wang Y,Yao Q,Zhao Y. Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice. Transpl Immunol. 2009; [Epub ahead of print]Hua Liang,Yongxiang Zhao,Zhonggui San,Chongxian Liao,Chuang Sha,Baiyi Xie,Jibing Chen,Junjie Xia,Yongzhi Wang,Zhongquan Qi(通讯作者). The recall alloresponse following retransplantation is more intense compared with the T cell memory-transfer model.Immunol Invest,2010 (accepted,manuscript ID: LIMM-2009-0045)Zhao Y,Zhang S,Zhou J,Wang J,Zhen M,Liu Y,Chen J,Qi Z*. The Development of a Tissue-Engineered Artery Using Decellularized Scaffold and Autologous Ovine Mesenchymal Stem Cells. Biomaterials 2009 Oct ; 31:296–307.(IF=6.6) (*通讯作者)Chen X,Shao W,Chen J,Zhang L,Corbascio M,Shi-Guang S and Qi Z*. Allotransplantation of Sulphate Glucomannan-Alginate
钡 (SGA) –Microencapsulated Rat Islets for the Treatment of
糖尿病 Mellitus. Immunological investigation 2009 July; 38:1-11. (*通讯作者)Xie B,Chen J,Xia J,Wang Y,Liang H,Henrik E,Matthias C and Qi Z*. Combined Costimulation Blockade Inhibits Accelerated Rejection Mediated by Allo
抗原Primed Memory T cells in Mice. Immunological investigation 2009 Oct;38:1-13. (*通讯作者)Wang Y,Chen J,Qin Q,Kuang X,Xia J,Xie B,Wang F and Qi Z*. Synergistic Effects of Isatidis and
他克莫司 in the Prevention of Acute Heart Rejection in
鼠科 Transplantation immunology 2009 Sep;22:5-11. (*通讯作者)Eriksson T,Wallin R,Hoglund P,Roth B,Qi Z,Ostraat O,Bjorkman S. Low bioavailability of rectally administered thalidomide. Am J Health Syst Pharm.2000 ; 57⒄: 1607-10.Oderup C,Malm H,Ekberg H,Qi Z,Veress B,Ivars F,Corbascio M. Costimulation blockade-induced cardiac allograft tolerance: inhibition of T cell expansion and accumulation of intragraft cD4(+)Foxp3(+) T cells. Transplantation. 2006 15; 82⑾: 1493-500.Zhang L,Qi Z,Shan S,Wu D,Sun Y,Ekberg H. The effects of leflunomide and FK 506 on rejection of xenografts in rat-to-mouse. Scand J Immunol. 2004; 59⑶: 255-60.Zaina S,Pettersson L,Thomsen AB,Chai CM,Qi Z,Thyberg J,Nilsson J. Shortened life span,bradycardia,and hypotension in mice with targeted expression of an Igf2 transgene in smooth muscle cells. Endocrinology 2003 ; 144⑹: 2695-703. Corbascio M,Mahanty H,Osterholm C,Qi Z,Pearson TC,Larsen CP,Freise CE,Ekberg H. Anti-lymphocyte
函数associated
抗原1 monoclonal antibody inhibits CD40
配体independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice. Transplantation 2002 ;74⑴:35-41.Corbascio M,Ekstrand H,Osterholm C,Qi Z,Simanaitis M,Larsen CP,Pearson TC,Riesbeck K,Ekberg H. CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely. Transpl Immunol. 2002 ; 10⑴: 55-61.Österholm C,Qi Z,Ekberg J,Veress B,Pyke C,Hedner U,Ekberg H. Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants. Am J Transplantation 2001 ; 1⑴: 29-37.Eriksson T,Wallin R,Hoglund P,Roth B,Qi Z,Ostraat O,Bjorkman S. Low bioavailability of rectally administered thalidomide. Am J Health Syst Pharm.2000 ; 57⒄: 1607-10.M Olausson,D Lukes,J Norrby,Qi Z,Ekberg H,Gannedahl G,Tufvesson G,Mjörnstedt L. Antithymocyte Globulin and Cyclosporine A are Synergistic in an Experimental Transplantation Tolerance Model in the Rat. Scand J Immunol .1999; 49⑴: 38-44.Qi Z,Tufveson G,Ekberg H. Tolerance or rejection : A delicate balance as judged by exposure of heart-transplanted rats to the immunomodulator Linomide. Scand J Immunol. 1999; 50⑷: 394-8.Qi Z,Simanaitis M,Ekberg H. Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts.Transpl Immunol. 1999; 7⑶: 169-75.Östraat Ö,Qi Z,Tufveson G,Hedlund G,Ekberg H. The effects of leflunomide and cyclosporin A on rejection of cardiac allograft in rat. Scand.J.Immuno. 1998; 48⑷: 379-88.Petersson E,Qi Z,Hedlund G,Ekberg H. Activation of donor-specific CTL in a tolerant recipient of cardiac allograft. Cell Immunol. 1998; 189⑴:19-24.Qi Z,Ekberg H. Malononitrilamides prevent and suppress allospecific antibody production. Transplant Proc. 1998 ; 30⑻: 3980. Qi Z,Ekberg H. Malononitrilamides 715 and 279 prolong rat cardiac allograft survival,reverse ongoing rejection,inhibit allospecific antibody production and interact positively with cyclosporin. Scand J Immunol. 1998; 48⑷: 379-88.Qi Z,Simanaitis M,Ekberg H. Malononitrilamides 715 and 279 prevent accelerated cardiac allograft rejection synergistically with cyclosporin A in presensitized rats. Transpl Immunol. 1998; 6⑵: 94-100.Östraat Ö,Qi Z,Olausson M,Tufveson G,Ekberg H. Mycophenolate mofetil,
硫唑嘌呤 and cyclophosphamide enhanced efficacy combined with cyclosporine in rat cardiac transplantation. Scand J Immunol. 1997; 45⑷: 343-8.Petersson E,Qi Z,Ekberg H,Ostraat O,Dohlsten M,Hedlund G. Activation of alloreactive natural killer cells is resistant to cyclosporine. Transplantation 1997 27; 63⑻: 1138-44.Qi Z,Riesbeck K,Östraat Ö,Tufvesson G,Ekberg H. Single dose anti-CD4 monoclonal antibody therapy for induction of tolerance to cardiac allografts in high- and low-responder rat strains. Transpl Immunol. 1997; 5⑶: 204-11.. Bjorkman S,Fyge A,Qi Z. Determination of the steady state tissue distribution of midazolam in the rat. J Pharm Sci. 1996; 85⑻: 887-9.Östraat Ö,Riesbeck K,Qi Z,Eriksson T,Schatz H,Ekberg H. Thalidomide prolonged graft survival in a rat cardiac transplant model but had no inhibitory effect on lymphocyte function in vitro. Transpl Immunol. 1996 ; 4⑵: 117-25.33. Bojrup M,Qi Z,Bjorkman S,et al. Bioavailability of cyclosporine in rats after intragastric administration: a comparative study of the L2-phase and two other lipid-based vehicles. Transpl Immunol. 1996; 4⑷: 313-7