齐忠权
厦门大学医院院长
齐忠权,男,1960年出生,隆德大学博士毕业,现任厦门大学器官移植研究所所长、厦门大学医学院副院长、厦门大学医院执行院长。他的研究方向为移植免疫和免疫排斥机理,学科专长为器官移植抗排斥对策及免疫细胞信号传导机制。他擅长进行器官移植手术,2006年入选美国医学卫生保健世界名人传记。
简介
齐忠权,教授、博士生导师,瑞典隆德大学博士毕业。现任厦门大学器官移植研究所所长、厦门大学医学院副院长、厦门大学医院执行院长,同时兼任哈尔滨医科大学教授、博士生导师、国际器官移植协会会员、国务院侨办第二届海外咨询委员会委员、福建省器官移植协会副主任委员、厦门市医学会常务理事。
学习与工作经历
教 育 情况
1979-1984 哈尔滨医科大学医疗系读大学
1994-1999 隆德大学医学院读博士
1999-2001 瑞典隆德大学马尔默市医院博士后
工 作 经历
1984-1991 哈尔滨医科大学附属第一医院外科:住院医师和助教
1991-1993 哈尔滨医科大学附属第一医院外科:主治医师和讲师
1993-1999 瑞典隆德大学马尔默医院外科:外科博士,客座医生
1999-现在 瑞典隆德大学马尔默医院移植外科:研究员,移植专家
2000-现在 哈尔滨医科大学,教授。
2003-现在 哈尔滨医科大学博士生导师
2005-现在 广西医科大学名誉教授
2006-现在 厦门大学医学院教授,厦门大学医学院副院长,厦门大学器官移植研究所所长
2008-现在 厦门大学医院院长。
获 奖 情况
1991 黑龙江省科技进步一等奖:“部分脾脏切除术”
1993 黑龙江省科技进步一等奖:“世界首例父子间异体劈裂脾移植”
1995 瑞典科技年会奖:“抗CD4单克隆抗体对大鼠心脏移植的抗排研究”
2006 2006年入典美国医学卫生保健世界名人传记《Who’s Who In Medicine And Healthcare》第7版年鉴。
2011 卢嘉锡导师奖
学术专长
齐忠权教授从事外科临床、科研工作近20余年,在普通外科学、腹部脏器移植学、移植免疫以及免疫抑制剂开发等领域有很深造诣,参加过500余例的人体肾脏、肝脏、胰腺移植手术,迄今已发表SCI论文近40篇,最高影响因子7.1。
科研成果
一、改良器官移植实验外科技术。齐忠权教授对动物移植模型进行了改良,创造了出袖套法小鼠心脏移植模型、小鼠小肠移植模型等新实验外科技术。
二、开发和筛选新型免疫抑制剂。齐忠权教授他在全世界首先阐明了免疫抑制剂MNA715和MNA279(来夫米衍生物)的完整分子式,并曾在欧洲某大型医药公司中主持过新型免疫抑制剂的筛选工作。近年来,通过与广西医科大学合作,从菘蓝中成功提取出了一种具免疫抑制和抗肿瘤作用的单体。
三、深入器官移植临床工作。齐忠权教授在瑞典土耳其等国主持以及参加的器官移植手术超过500余例,临床经验十分丰富。
四、移植免疫相关研究。齐忠权教授有深厚的科研积累,在学界内有一定影响力。
主持科研项目
在瑞典期间,主持的课题主要有:
⑴ The development of new compounds which inhibit the acute rejection using rat heart transplant model. (Active Biotech AB,Lund,Sweden2001-2004)经费150,000美元
⑵ Tutor for the international course of microsurgery,and scientific adviser (DiLab,Lund,Sweden 2003-2006)经费30,000美元
⑶ Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants. (Novo Nordisk,Denmark 2003-2006)经费60,000美元
回国后,主持的课题主要有:
⑴ 活体肾脏移植的系列研究
厦门大学科研启动经费 2007-2011)经费300万人民币
⑵ 胰岛细胞和肾脏移植治疗糖尿病肾病的研究
福建省卫生科技联合攻关项目 2008-2011)经费30万人民币
⑶ 抗CD40-L和抗LFA-1单抗在预防异种胰岛移植排斥中的作用
厦门市科技项目 2009-2011)经费10万人民币
菘蓝组酸单体抗肿瘤及抗器官移植排斥双重作用的研究
(福建省科技重点项目2010-2013)经费15万人民币
专利情况
高级脂肪酸衍生物类新化合物及其制备方法和抗肿瘤用途
专利公开号:CN101475506A
专著情况
《活体供肾肾脏移植临床规范》
作者:齐忠权 Henrik Ekberg(瑞典
Wolters Kluwer Health Co.Ltd 于2009年12月出版
论著情况
Junjie Xia,1 Jibing Chen,2 Wei Shao,1 Tianshu Lan,1 Yongzhi Wang,1 Baiyi Xie,1 Henrik Thorlacius,3 Feng Tian,2 Ruxin Huang,4 Zhongquan Qi,Suppressing memory T cell activation induces islet allograft tolerance in allo抗原primed mice. Transplant International. (*通讯作者)(accepted 2010)Feng Wang,JibingChen,WeiShao,Baiyi Xie,YongzhiWang,TianshuLan,HenrikThorlacius,Zhongquan Qi. Anti-CD44 Monoclonal Antibody Inhibits Heart Transplant Rejection Mediated by Allo抗原primed CD4+Tm in Nude Mice. Transplant Immunology. (*通讯作者)(accepted 2010)Lan Tianshu,Chen Jibing,Kang Xiangpeng,Wang Feng,Wang Yongzhi,Xia Junjie,Qi Zhongquan. Pre-contact of tolerance circumstance protect the allograft from attacking by memory T cells. Scandinavian Journal of Immunology(*通讯作者)(accepted 2010)Xiangpeng Kang,Jibing Chen,Qing Qin,Feng Wang,Yongzhi Wang,Tianshu Lan,Shuo Xu,Feiyu Wang,Junjie Xia,Henrik Ekberg,Zhongquan Qi,Zhongchen Liu.Isatis tinctoria L. combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in allo抗原primed mice. Transpl Immunol. (*通讯作者)(accepted 2010)Baiyi Xie,Jibing Chen,Feng Wang,Tianshu Lan,Yongzhi Wang,Junjie Xia,Zhi Li,Qingxiang Xie,Ruxin Huang,Zhongquan Qi. Monoclonal Antibody Treatment to Prolong the Secondary Cardiac Allograft Survival in Allo抗原primed 鼠科 Scandinavian Journal of Immunology. (*通讯作者)(accepted 2010)Liang H,Liao C,Qi Z,Sha C,Xie B,Chen J,Xia J,Wang Y,Yao Q,Zhao Y. Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4(+) memory T cells in mice. Transpl Immunol. 2009; [Epub ahead of print]Hua Liang,Yongxiang Zhao,Zhonggui San,Chongxian Liao,Chuang Sha,Baiyi Xie,Jibing Chen,Junjie Xia,Yongzhi Wang,Zhongquan Qi(通讯作者). The recall alloresponse following retransplantation is more intense compared with the T cell memory-transfer model.Immunol Invest,2010 (accepted,manuscript ID: LIMM-2009-0045)Zhao Y,Zhang S,Zhou J,Wang J,Zhen M,Liu Y,Chen J,Qi Z*. The Development of a Tissue-Engineered Artery Using Decellularized Scaffold and Autologous Ovine Mesenchymal Stem Cells. Biomaterials 2009 Oct ; 31:296–307.(IF=6.6) (*通讯作者)Chen X,Shao W,Chen J,Zhang L,Corbascio M,Shi-Guang S and Qi Z*. Allotransplantation of Sulphate Glucomannan-Alginate (SGA) –Microencapsulated Rat Islets for the Treatment of 糖尿病 Mellitus. Immunological investigation 2009 July; 38:1-11. (*通讯作者)Xie B,Chen J,Xia J,Wang Y,Liang H,Henrik E,Matthias C and Qi Z*. Combined Costimulation Blockade Inhibits Accelerated Rejection Mediated by Allo抗原Primed Memory T cells in Mice. Immunological investigation 2009 Oct;38:1-13. (*通讯作者)Wang Y,Chen J,Qin Q,Kuang X,Xia J,Xie B,Wang F and Qi Z*. Synergistic Effects of Isatidis and 他克莫司 in the Prevention of Acute Heart Rejection in 鼠科 Transplantation immunology 2009 Sep;22:5-11. (*通讯作者)Eriksson T,Wallin R,Hoglund P,Roth B,Qi Z,Ostraat O,Bjorkman S. Low bioavailability of rectally administered thalidomide. Am J Health Syst Pharm.2000 ; 57⒄: 1607-10.Oderup C,Malm H,Ekberg H,Qi Z,Veress B,Ivars F,Corbascio M. Costimulation blockade-induced cardiac allograft tolerance: inhibition of T cell expansion and accumulation of intragraft cD4(+)Foxp3(+) T cells. Transplantation. 2006 15; 82⑾: 1493-500.Zhang L,Qi Z,Shan S,Wu D,Sun Y,Ekberg H. The effects of leflunomide and FK 506 on rejection of xenografts in rat-to-mouse. Scand J Immunol. 2004; 59⑶: 255-60.Zaina S,Pettersson L,Thomsen AB,Chai CM,Qi Z,Thyberg J,Nilsson J. Shortened life span,bradycardia,and hypotension in mice with targeted expression of an Igf2 transgene in smooth muscle cells. Endocrinology 2003 ; 144⑹: 2695-703. Corbascio M,Mahanty H,Osterholm C,Qi Z,Pearson TC,Larsen CP,Freise CE,Ekberg H. Anti-lymphocyte 函数associated 抗原1 monoclonal antibody inhibits CD40 配体independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice. Transplantation 2002 ;74⑴:35-41.Corbascio M,Ekstrand H,Osterholm C,Qi Z,Simanaitis M,Larsen CP,Pearson TC,Riesbeck K,Ekberg H. CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely. Transpl Immunol. 2002 ; 10⑴: 55-61.Österholm C,Qi Z,Ekberg J,Veress B,Pyke C,Hedner U,Ekberg H. Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants. Am J Transplantation 2001 ; 1⑴: 29-37.Eriksson T,Wallin R,Hoglund P,Roth B,Qi Z,Ostraat O,Bjorkman S. Low bioavailability of rectally administered thalidomide. Am J Health Syst Pharm.2000 ; 57⒄: 1607-10.M Olausson,D Lukes,J Norrby,Qi Z,Ekberg H,Gannedahl G,Tufvesson G,Mjörnstedt L. Antithymocyte Globulin and Cyclosporine A are Synergistic in an Experimental Transplantation Tolerance Model in the Rat. Scand J Immunol .1999; 49⑴: 38-44.Qi Z,Tufveson G,Ekberg H. Tolerance or rejection : A delicate balance as judged by exposure of heart-transplanted rats to the immunomodulator Linomide. Scand J Immunol. 1999; 50⑷: 394-8.Qi Z,Simanaitis M,Ekberg H. Malononitrilamides and tacrolimus additively prevent acute rejection in rat cardiac allografts.Transpl Immunol. 1999; 7⑶: 169-75.Östraat Ö,Qi Z,Tufveson G,Hedlund G,Ekberg H. The effects of leflunomide and cyclosporin A on rejection of cardiac allograft in rat. Scand.J.Immuno. 1998; 48⑷: 379-88.Petersson E,Qi Z,Hedlund G,Ekberg H. Activation of donor-specific CTL in a tolerant recipient of cardiac allograft. Cell Immunol. 1998; 189⑴:19-24.Qi Z,Ekberg H. Malononitrilamides prevent and suppress allospecific antibody production. Transplant Proc. 1998 ; 30⑻: 3980. Qi Z,Ekberg H. Malononitrilamides 715 and 279 prolong rat cardiac allograft survival,reverse ongoing rejection,inhibit allospecific antibody production and interact positively with cyclosporin. Scand J Immunol. 1998; 48⑷: 379-88.Qi Z,Simanaitis M,Ekberg H. Malononitrilamides 715 and 279 prevent accelerated cardiac allograft rejection synergistically with cyclosporin A in presensitized rats. Transpl Immunol. 1998; 6⑵: 94-100.Östraat Ö,Qi Z,Olausson M,Tufveson G,Ekberg H. Mycophenolate mofetil,硫唑嘌呤 and cyclophosphamide enhanced efficacy combined with cyclosporine in rat cardiac transplantation. Scand J Immunol. 1997; 45⑷: 343-8.Petersson E,Qi Z,Ekberg H,Ostraat O,Dohlsten M,Hedlund G. Activation of alloreactive natural killer cells is resistant to cyclosporine. Transplantation 1997 27; 63⑻: 1138-44.Qi Z,Riesbeck K,Östraat Ö,Tufvesson G,Ekberg H. Single dose anti-CD4 monoclonal antibody therapy for induction of tolerance to cardiac allografts in high- and low-responder rat strains. Transpl Immunol. 1997; 5⑶: 204-11.. Bjorkman S,Fyge A,Qi Z. Determination of the steady state tissue distribution of midazolam in the rat. J Pharm Sci. 1996; 85⑻: 887-9.Östraat Ö,Riesbeck K,Qi Z,Eriksson T,Schatz H,Ekberg H. Thalidomide prolonged graft survival in a rat cardiac transplant model but had no inhibitory effect on lymphocyte function in vitro. Transpl Immunol. 1996 ; 4⑵: 117-25.33. Bojrup M,Qi Z,Bjorkman S,et al. Bioavailability of cyclosporine in rats after intragastric administration: a comparative study of the L2-phase and two other lipid-based vehicles. Transpl Immunol. 1996; 4⑷: 313-7
Östraat Ö,Qi Z,Olausson M,Gannedahl G,Tufveson G,Ekberg H. Additive immunosuppressive effect of combined mycophenolate mofetil and cyclosporin A in experimental rat cardiac transplantation. Transplant Proc.1995; 27⑹: 3540.Östraat Ö,Qi Z,Gannedahl G,Tufveson G,Ekberg H. Moderate additive immunosuppressive effect of thalidomide combined with cyclosporin A in rat cardiac transplantation. Transpl Immunol. 1996; 4⑶: 241-6.姜洪池;李广华;吴业权;曲英贵;单世光;齐忠权;刘杰;武林枫;王阿丽;夏穗生。脾被膜移植的规则性部分脾切除术(附18例报告)。中华实验外科杂志,1991,(03).张树才,单世光,宋东,齐忠权,洪大卫,薛兴文,侯全吉,魏林玉。对脾手术若干问题的探讨。哈尔滨医科大学学报,1992,(03).齐忠权,单世光,王国卿,姜洪池,李智勋,吴业权,李广华。部分脾切除术脾断面处理的实验研究。中华实验外科杂志,1992,9⑴乔海泉,单世光,姜洪池,齐忠权,吴业权,张树才,侯利民。非门脉相续性部分脾脏移植的研究。中华实验外科,1994,11⑴
参考资料
目录
概述
简介
学习与工作经历
获 奖 情况
学术专长
科研成果
主持科研项目
专利情况
专著情况
论著情况
参考资料